Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
//genesis
//connect_utility_pre

//Pre-synaptic

//str Netpath="/network/SPcell[]", comp_name

function pre (Net1, Net2)
echo "in pre"
str Net1, Net2, comp_name

int cnt, i, tot_cnt=0

foreach comp_name ({el {Net1}/soma}) 
  cnt = {getmsg {comp_name}/spike -out -count} 
  if ({cnt}>1)
    ce {comp_name}
    ce ..
    echo "" >> connect_pre.log   
    echo "Pre-synaptic location" >> connect_pre.log
    pwe >> connect_pre.log  
    echo "Post-synaptic SP connections" >> connect_pre.log
    for (i = 0; i < {cnt}; i= {i +1})
        echo {getmsg {comp_name}/spike -out -destination {i}} >> connect_pre.log  
    end       
  else
  end 
end

end

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