Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
//genesis
//net_conn.g - Description of the FS and SP connections to the SP network

//This file sets up the SP-SP connections based on the factor sent to the netconn function



  for(ctrpre = 0; ctrpre < {getglobal numCells_{net}}; ctrpre = {ctrpre + 1})  //loops through presynaptic cells
        xpre={getfield {network}[{ctrpre}]/soma/ x}  //get x location
	ypre={getfield {network}[{ctrpre}]/soma/ y}  //get y location

	for(ctrpost = 0; ctrpost < {getglobal numCells_{net2}}; ctrpost= {ctrpost +1})  //loops through postsynaptic cells

		if ({ctrpre}!={ctrpost}) //only if pre and post synaptic cells are different start connecting                                                                                                 
                   xpost={getfield {network2}[{ctrpost}]/soma/ x} //get x location
		   ypost={getfield {network2}[{ctrpost}]/soma/ y} //get y location

                   dist2parent={{pow {xpost-xpre} 2 } + {pow {ypost-ypre} 2}}   // calculating distance between the cells               
             

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