Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

 Download zip file 
Help downloading and running models
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
// This code creates a MS spine that can be added on any dendrite
// The initial purpose is to test if GABA synapses on the neck of the spine
// can block a bAP depolarisation from reaching the spine head.
// There are reconstructed MS spines in the DATA/ directory.

function createSpine(spineName, spineLoc, \
                     neckLen, neckDia, nNeck, \
                     HeadLen, HeadDia, nHead)

str spineName // Name of spine
str spineLoc  // Location of spine (compartment it is attached to)
float neckLen // Length of the spine neck
float neckDia // Diameter of spine neck
int nNeck     // Number of neck compartments (1 or more)
float HeadLen // Length of spine head
float HeadDia // Diameter of spine head
int nHead     // Number of compartments in spine head (2 or more),
              // ie submembrane shell + rest of head

pushe {spineLoc}

  int i

  str parentComp = {spineLoc}

  for(i = 0; i < {nNeck}; i = i + 1)
    create compartment spineNeck[{i}]

    addmsg spineNeck[{i}] {parentComp} RAXIAL Ra previous_state
    addmsg {parentComp} spineNeck[{i}] AXIAL previous_state

    makeCaBuffer CaTbuf {spineLoc}/spineNeck[{i}]

    parentComp = spineNeck[{i}]

  // One compartment is dedicated to submembrane, has separate name
  int nHeadRest = {{nHead}-1}

  for(i = 0; i < {nHeadRest}; i = i + 1)
    create compartment spineHead[{i}]

    addmsg spineHead[{i}] {parentComp} RAXIAL Ra previous_state
    addmsg {parentComp} spineHead[{i}] AXIAL previous_state

    makeCaBuffer CaNQRbuf {spineLoc}/spineHead[{i}]

    createCaChannelsFromList "CaN CaNNOINACT CaQ" \
                             {spineLoc}/spineHead[{i}] \

    float SKcond = 0.145e4
    copyAndConnectSKKchannels {spineLoc}/spineHead[{i}] CaNQRbuf {SKcond}

    parentComp = spineHead[{i}]

  // Submembrane compartment added seperately
  create compartment spineHeadEnd
  addmsg spineHeadEnd {parentComp} RAXIAL Ra previous_state
  addmsg {parentComp} spineHeadEnd AXIAL previous_state

  makeCaBuffer CaTbuf {spineLoc}/spineHeadEnd

  float AMPAcond = 80e-12
  float NMDAcond = 220e-12

  addAMPAchannelGHKCa {spineLoc}/spineHeadEnd {AMPAcond}
  addNMDAchannelGHKCa {spineLoc}/spineHeadEnd {NMDAcond}

  createCaChannelsFromList "CaL13 CaL12 CaL12NOINACT" \
                           {spineLoc}/spineHeadEnd \

pope {spineLoc}


function addGabaToSpine(spineName, spineLoc, neckIdx)

str spineName
str spineLoc
int neckIdx

float GABAcond = 750e-12

addGABAchannel {spineLoc}/spineNeck[{neckIdx}] {GABAcond}

Loading data, please wait...