Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
spine
MSspine.g
randomize2-2.g
SPnet_test.g
                            
// This code creates a MS spine that can be added on any dendrite
//
// The initial purpose is to test if GABA synapses on the neck of the spine
// can block a bAP depolarisation from reaching the spine head.
//
//
// There are reconstructed MS spines in the DATA/ccdb.ucsd.edu directory.

function createSpine(spineName, spineLoc, \
                     neckLen, neckDia, nNeck, \
                     HeadLen, HeadDia, nHead)

str spineName // Name of spine
str spineLoc  // Location of spine (compartment it is attached to)
float neckLen // Length of the spine neck
float neckDia // Diameter of spine neck
int nNeck     // Number of neck compartments (1 or more)
float HeadLen // Length of spine head
float HeadDia // Diameter of spine head
int nHead     // Number of compartments in spine head (2 or more),
              // ie submembrane shell + rest of head

pushe {spineLoc}

  int i

  str parentComp = {spineLoc}

  for(i = 0; i < {nNeck}; i = i + 1)
    create compartment spineNeck[{i}]

    addmsg spineNeck[{i}] {parentComp} RAXIAL Ra previous_state
    addmsg {parentComp} spineNeck[{i}] AXIAL previous_state

    makeCaBuffer CaTbuf {spineLoc}/spineNeck[{i}]

    parentComp = spineNeck[{i}]
  end

  // One compartment is dedicated to submembrane, has separate name
  int nHeadRest = {{nHead}-1}

  for(i = 0; i < {nHeadRest}; i = i + 1)
    create compartment spineHead[{i}]

    addmsg spineHead[{i}] {parentComp} RAXIAL Ra previous_state
    addmsg {parentComp} spineHead[{i}] AXIAL previous_state

    makeCaBuffer CaNQRbuf {spineLoc}/spineHead[{i}]

    createCaChannelsFromList "CaN CaNNOINACT CaQ" \
                             {spineLoc}/spineHead[{i}] \
                             CaNQRbuf   

    float SKcond = 0.145e4
    copyAndConnectSKKchannels {spineLoc}/spineHead[{i}] CaNQRbuf {SKcond}

    parentComp = spineHead[{i}]
  end

  // Submembrane compartment added seperately
  create compartment spineHeadEnd
  addmsg spineHeadEnd {parentComp} RAXIAL Ra previous_state
  addmsg {parentComp} spineHeadEnd AXIAL previous_state

  makeCaBuffer CaTbuf {spineLoc}/spineHeadEnd

  float AMPAcond = 80e-12
  float NMDAcond = 220e-12

  addAMPAchannelGHKCa {spineLoc}/spineHeadEnd {AMPAcond}
  addNMDAchannelGHKCa {spineLoc}/spineHeadEnd {NMDAcond}

  createCaChannelsFromList "CaL13 CaL12 CaL12NOINACT" \
                           {spineLoc}/spineHeadEnd \
                           CaTbuf

pope {spineLoc}

end

function addGabaToSpine(spineName, spineLoc, neckIdx)

str spineName
str spineLoc
int neckIdx

float GABAcond = 750e-12

addGABAchannel {spineLoc}/spineNeck[{neckIdx}] {GABAcond}
 
end

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