Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
Conditions
No_DA
MScell
channels
unusedChannels
#MScell08CM3_D1.p#
AddCaSpines.g *
addchans.g *
addinput.g *
addoutput.g *
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globalsCaComp.g *
include_channels.g *
MScell.p *
MScell_D1.g *
MScell_D1_old.g *
MScell_D2.g *
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
spines.g *
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//genesis
//SynParams.g

	str AMPAname = "AMPA"
	float EkAMPA = 0.0
        float AMPAtau1 = 1.1e-3
        float AMPAtau2 = 5.75e-3 
        float AMPAgmax = 0.47e-9  //593e-12 I changed this to make the NMDA/AMPA ratio more like 2.75/1 which is what Ding 2008 finds int corticalstriatal synapses
									//more like 2/1 for thalamus so should be 0.47e-9 for thalamo-striatal syanpnse if NMDA is 0.94e-9 Rebekah Evans 6/25/10
									//really should ampa change or NMDA change to get the right ratio? either NMDA=0.94 and ampa=0.47	
									//or AMPA=0.342 and NMDA = 0.0.684	

									str GABAname = "GABA"
        float GABAtau1 = 0.25e-3    // From Galarreta and Hestrin 1997 
        float GABAtau2 = 3.75e-3    //(used in Wolfs model)
        float EkGABA = -0.060
        float GABAgmax = 750e-12  //Modified Koos 2004 (Wolf uses 435e-12)

	int GABA2Spine = 0                                // = 0, No GABA; 
                                                  //   1, add GABA to spine head
                                                  //   2, add GABA to spine neck
	
	int addCa2Spine = 1		// 0, no ca channels in spine, 
					//1, yes ca channels in spine (non-synaptic)
	int NMDABufferMode = 0          // 1, connect both NMDA and AMPA calcium to NMDA_buffer
                                     // 0, connect only NMDA currents to NMDA_buffer

float useAMPANMDAGHKchannels= 0  // we do not use GHK project for NMDA/AMPA

setclock 0 5e-6 //was 5e-6
        // Simulation time step (Second)       
setclock 1 2e-5        //  time step for ascii output
//setclock 1 1e-4 // time step for graphic output


// parameters for NMDA subunits


// cortex
str	    subunit = "Thalamus"
float   EkNMDA   = 0
float	Kmg       = 3.57
float	NMDAtau2      = (155e-3)/2 	//thal avg for .42 NR2B and .58 NR2A.  (300e-3)/2 (NR2B) (50e-3)/2 (NR2A) 126+29 = 155
float	NMDAgmax      = 0.94e-9      //NR2A and B from (Moyner et al., 1994 figure 7)
int ghk_yesno=0

str NMDAname = {subunit}

//for saving info on distal or proximal dendrites or massed and spaced. formula typeof dend, # of spines.

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