Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
Conditions
No_DA
MScell
channels
unusedChannels
#MScell08CM3_D1.p#
AddCaSpines.g *
addchans.g *
addinput.g *
addoutput.g *
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globalsCaComp.g *
include_channels.g *
MScell.p *
MScell_D1.g *
MScell_D1_old.g *
MScell_D2.g *
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
spines.g *
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//genesis
//include_channels.g
/*******
AB: removed CaNNOINACT_channel and CaL12NOINACT_channel by combining with inactivating channels
AB: deleted CaQ because no evidence for such in SP, and doesn't contribute much anyway
AB: Also, removed KRP channels from here because we're not using them
AB: no longer making naP in the library since it is not used, and has been moved to a different directory
**********/

include MScell/channels/tabchanforms.g
//calcium channels
include MScell/channels/CaL12inact_channel
include MScell/channels/CaL13_channel
include MScell/channels/CaNinact_channel
//include MScell/channels/CaQ_channel
include MScell/channels/CaR_channel
include MScell/channels/CaT_channel

//voltage dependent channels
include MScell/channels/naF_chanOg
//include MScell/channels/naP_channel
include MScell/channels/kAf_chanRE
include MScell/channels/kIR_chanKD
include MScell/channels/kAs_chanRE
include MScell/channels/K_DR_channel

//calcium dependent potassium channels
include MScell/channels/BKKchannel
include MScell/channels/SKchannelCaDep



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