Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

 Download zip file 
Help downloading and running models
Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum spiny direct pathway neuron; Neostriatum spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
/
DamodaranEtAl2015
Conditions
No_DA_No_G
FScell
channels
AddSynapticChannels.g *
cellMorphology.g *
errorHandler.g *
FScell.g *
FScell.p *
FScellSyn.g *
include_channels.g *
proto.g *
SynParams.g *
                            
//genesis
//FScellSyn.g
//This routine takes the FScell without synapses, and adds synapses

include FScell/FScell.g                 //FScell without synapses
include FScell/SynParams.g               //parameters on synaptic channels
include FScell/channels/synaptic_channel.g // function to make non nmda synaptic channels in library
include FScell/AddSynapticChannels.g	// contains functions to add channels to compartments

function makeFScellSyn (cellname,pfile)
   str cellname,pfile

   str CompName

   make_FS_cell {cellname} {pfile}

	//************* create synaptic channels in library *********
	pushe /library

  	make_synaptic_channel  {AMPAname} {AMPAtau1} {AMPAtau2} {AMPAgmax} {EkAMPA}
  	make_synaptic_channel  {GABAname} {GABAtau1} {GABAtau2} {GABAgmax} {EkGABA}

        pope {cellname}
	
   //********************* end synaptic channels in library **************

      foreach CompName ({el {cellname}/##[TYPE=compartment]}) 
        addSynChannel  {CompName} {AMPAname} {AMPAgmax}
        addSynChannel  {CompName} {GABAname} {GABAgmax}
      end


end

Loading data, please wait...