Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
FScell
channels
a_channel.g *
ampa_channel.g *
gaba_channel.g *
k13_channel.g *
k3132_channel.g *
na_channel.g *
synaptic_channel.g *
                            
/* 
 * interneuron simulation
 * Copyright (C) 2000 Rory Kirchner (rory@mail.csh.rit.edu)
 *
 * This program is free software; you can redistribute it and/or
 * modify it under the terms of the GNU General Public License
 * as published by the Free Software Foundation; either version 2
 * of the License, or (at your option) any later version.
 *
 * This program is distributed in the hope that it will be useful,
 * but WITHOUT ANY WARRANTY; without even the implied warranty of
 * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
 * GNU General Public License for more details.
 * 
 * You should have received a copy of the GNU General Public License
 * along with this program; if not, write to the Free Software
 * Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA
 *
 */

function make_AMPA_channel

   str chanpath = "AMPA"
// see  Gotz T, et al, 1997
// here adjusted to Avramas data
   float tau1 = 0.67e-3 // was 1e-3 before

// from Gotz et al, and Angulo et al 1997
// here adjusted to Avramas data instead
   float tau2 = 2e-3  //was 1 and 3e-3 before 

   float gmax = 0
   float Ek = 0.0

   echo "chanpath = "{chanpath}
   
   create synchan {chanpath}

   setfield {chanpath} tau1 {tau1} tau2 {tau2} gmax {gmax} Ek {Ek}

end



















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