Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
//IF.g
/*
step 0.10 -time
setfield {cellpath}/soma inject 0.5e-9 
step 0.25 -time
setfield {cellpath}/soma inject 0
step 0.1 -time
*/
//setfield /data/soma overlay 1
reset
int i = 0
float inj = 400e-12

for (i=0; i<1; i=i+1)
	echo {inj} = "I inject"
	//step 0.1  -time
	setfield /FSnetwork/FScell[0]/soma inject {inj}
	step 0.5    -time
	setfield /FSnetwork/FScell[0]/soma inject 0.0e-9
	//step 0.2 -time
	inj= {inj}+50.0e-12
	//reset
end

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