Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of Fast-Spiking Interneurons Reduces beta-Band Oscillations and Imbalance in Firing in the Dopamine-Depleted Striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway neuron; Neostriatum medium spiny indirect pathway neuron; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
MScell
channels
unusedChannels
AddCaSpines.g *
addchans.g *
addinput.g *
addoutput.g *
addoutput_old.g *
AddSynapticChannels.g *
connectCaChannels.g *
DA_files.txt *
globals.g
globalsCaComp.g *
include_channels.g *
MScell.p *
MScell_D1.g *
MScell_D1_old.g *
MScell_D2.g *
MScell08.p *
MScell08CM3_D1.p *
MScell08CM3_D2.p *
MScellSpine.g *
MScellSpineCtx.g *
MScellSpineTh.g *
MScellSyn_D1.g *
MScellSyn_D2.g *
parametersA_D1.g *
parametersA_D2.g *
parametersB.g *
parametersC.g *
parametersD.g *
proto.g *
spines.g *
SynParams_D1.g
SynParams_D2.g
SynParamsCtx.g *
SynParamsTh.g *
                            
//genesis
//MScellSyn.g
//This routine takes the MScell without synapses, and adds synapses

include MScell/MScell_D1.g                 //MScell without synapses
include MScell/SynParams_D1.g               //parameters on synaptic channels
include MScell/channels/nmda_channel.g   //function to make nmda channel, either GHK or not, in library
include MScell/channels/synaptic_channel.g // function to make non nmda synaptic channels in library
include MScell/AddSynapticChannels.g	// contains functions to add channels to compartments

function makeMScellSyn (cellname,pfile)
   str cellname,pfile

   str CompName

   make_MS_cell {cellname} {pfile}

	//************* create synaptic channels in library *********
	pushe /library

  	make_synaptic_channel  {AMPAname} {AMPAtau1} {AMPAtau2} {AMPAgmax} {EkAMPA}
  	make_NMDA_channel    {NMDAname} {EkNMDA} {Kmg} {NMDAtau2} {NMDAgmax} {ghk_yesno}
	make_synaptic_channel  {GABAname} {GABAtau1} {GABAtau2} {GABAgmax} {EkGABA}

        pope {cellname}
	
   //********************* end synaptic channels in library **************

      foreach CompName ({el {cellname}/##[TYPE=compartment]}) 
        addNMDAchannel {CompName} {NMDAname} {CA_BUFF_3} {NMDAgmax} {ghk_yesno}
        addSynChannel  {CompName} {AMPAname} {AMPAgmax}
        addSynChannel  {CompName} {GABAname} {GABAgmax}
      end
  ce /

end

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