Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
MScell
channels
ampa_channel.g *
BKKchannel.g *
CaL12inact_channel.g *
CaL13_channel.g *
CaNinact_channel.g *
CaR_channel.g *
CaT_channel.g *
gaba_channel.g
K_DR_channel.g *
kAf_chanRE.g *
kAs_chanRE.g *
kIR_chanKD.g *
naF_chanOg.g *
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis

/***************************		MS Model, Version 5.11	**********************
**************************** 	      	K_DR_channel.g 	**********************
Tom Sheehan tsheeha2@gmu.edu	thsheeha@vt.edu	703-538-8361
******************************************************************************/
/* AB: replaced q10 with qfactor, which now modifies time constants of channels
* qfactor=0.5 means that channels have been slowed down to produce wider spikes
*/

//************************ Begin Primary Routine ******************************
//*****************************************************************************
function make_K_DR_channel
	//********************* Begin Local Variables ******************************
   float xmin = -0.1
   float xmax = 0.05
   int xdivs = 3000
   float x,dx,alpha_m,beta_m,tau_m,m_inf
   int i
   float  qfactor = 0.5   
   float Erev = -0.09    
	//********************* End Local Variables ********************************

 	if ({exists K_DR})
		echo "K_DR tabchannel exists"
   	return
 	end
 
 	create tabchannel K_DR 
  	setfield ^ Ek {Erev} 	\
             Gbar 100.0 	\ 
             Ik 0        	\
             Gk 0        	\
             Xpower 1    	\
             Ypower 0    	\
             Zpower 0 

  	call K_DR TABCREATE X {xdivs} {xmin} {xmax}
        dx = (xmax-xmin)/xdivs
        x = xmin
	echo "K_DR increment:" {dx} "V"
   for (i=0;i<={xdivs};i=i+1)

		/*migliore, et,al 1999 */
      alpha_m =1000.0*({exp {-110*(x+0.013)}} )
      beta_m  =1000.0*({exp {-80*(x+0.013)}}) 
      tau_m = {{0.001*50*beta_m/(1e3+alpha_m)}/qfactor}
      m_inf = 1000.0/(1000.0+alpha_m)
      setfield K_DR X_A->table[{i}] {tau_m}
      setfield K_DR X_B->table[{i}] {m_inf}
      x = x+dx
   end

   tweaktau K_DR X 
 
   setfield K_DR X_A->calc_mode 1 X_B->calc_mode 1
end
//************************ End Primary Routine ********************************
//*****************************************************************************

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