Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
MScell
channels
ampa_channel.g *
BKKchannel.g *
CaL12inact_channel.g *
CaL13_channel.g *
CaNinact_channel.g *
CaR_channel.g *
CaT_channel.g *
gaba_channel.g
K_DR_channel.g *
kAf_chanRE.g *
kAs_chanRE.g *
kIR_chanKD.g *
naF_chanOg.g *
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
//genesis
//nmda_channel.g

function make_NMDA_channel (chanpath, Ek, KMg, tau2, gmax, ghk)

  str chanpath //what you want the channel to be called (full path)
  float KMg, tau2, gmax  //parameters that differ between NR2A, B, C and D subunits
  
  float Ek
  int ghk 
  
  float tau1 = (4.4624e-3)/2 //  DE Chapman et al 2003, table 1 (12.13/e=5.63ms)
  float CMg = 1  // [Mg] in mM

  float eta = 1/3.57  // per mM
  float gamma = 62  // per Volt

	echo "XXXXXXXXXXXXXXX make_NMDA_channel XXXXXXXXXXXXXXXX"
	echo "chanpath = "{chanpath}
	echo "caBuffer = "{Ek}
	echo "KMg = "{KMg}
	echo "tau2 = "{tau2}
	echo "gmax = "{gmax}
	echo "XXXXXXXXXXXXXXX make_NMDA_channel XXXXXXXXXXXXXXXX"

	create synchan {chanpath}
	setfield {chanpath} \
          Ek   {Ek}   \
          tau1 {tau1} \
          tau2 {tau2} \
          gmax {gmax/2}
   
//the kinetics of the magnesium block is different for different subunits.  
// NR2A and B are about the same, but C and D are much less affected by the block.  
//these numbers were used because the made the magnesium block curve fit the figures by Moyner et al (1994 figure 7) best by eye.

  create Mg_block {chanpath}/block
  setfield {chanpath}/block CMg {CMg} 
  setfield {chanpath}/block KMg_B {1.0/{gamma}}
  setfield {chanpath}/block KMg_A {KMg}
				
  addmsg {chanpath} {chanpath}/block CHANNEL Gk Ek

  if (ghk==1)
     create ghk {chanPath}/GHK
     setfield {chanPath}/GHK Cout 2 // Carter & Sabatini 2004 uses 2mM, Wolf 5mM
     setfield {chanPath}/GHK valency 2.0
     setfield {chanPath}/GHK T {temperature}
     addmsg {compPath}/{chanpath}/block {chanPath}/GHK PERMEABILITY Gk 
  end

end


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