Striatal NN model of MSNs and FSIs investigated effects of dopamine depletion (Damodaran et al 2015)

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Accession:169984
This study investigates the mechanisms that are affected in the striatal network after dopamine depletion and identifies potential therapeutic targets to restore normal activity.
Reference:
1 . Damodaran S, Cressman JR, Jedrzejewski-Szmek Z, Blackwell KT (2015) Desynchronization of fast-spiking interneurons reduces ß-band oscillations and imbalance in firing in the dopamine-depleted striatum. J Neurosci 35:1149-59 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Axon; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum fast spiking interneuron;
Channel(s): I Sodium; I Potassium; Kir;
Gap Junctions: Gap junctions;
Receptor(s): D1; D2; GabaA; Glutamate;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Synchronization; Detailed Neuronal Models; Parkinson's;
Implementer(s): Damodaran, Sriraman [dsriraman at gmail.com];
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; D1; D2; GabaA; Glutamate; I Sodium; I Potassium; Kir; Gaba; Glutamate;
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DamodaranEtAl2015
MScell
channels
ampa_channel.g *
BKKchannel.g *
CaL12inact_channel.g *
CaL13_channel.g *
CaNinact_channel.g *
CaR_channel.g *
CaT_channel.g *
gaba_channel.g
K_DR_channel.g *
kAf_chanRE.g *
kAs_chanRE.g *
kIR_chanKD.g *
naF_chanOg.g *
nmda_channel.g *
SKchannelCaDep.g *
synaptic_channel.g *
tabchanforms.g *
                            
/*form call file for creating tab channels*/


function exp_form (rate, slope, V)
	float rate,slope,V
	//equation is ({rate} *(exp (-{V}/{slope}) ))
	float numx ={{-V}/{slope}}
	float expx = {exp {numx}}
	float entry = ({rate}*{expx})
	return {entry}
end

function sig_form (rate, vhalf, slope, V)
	float rate, vhalf, slope, V
	//equation is ({rate}/(exp ({{V}-{vhalf}}/{slope})+1))
	//rate/(EXP((v-vhalf)/slope)+1)
	float numx = {{{V}-{vhalf}}/{slope}}
	float expx = {exp {numx}}
	float entry = ({rate}/{{expx}+1})
	return {entry}
end

function lin_form (rate, vhalf, slope, V)

	float rate, vhalf, slope, V
	//equation is (({rate}*({V}-{vhalf}))/{exp ({v}-{vhalf}/{slope})-1)})
	float numx = {{{{V}-{vhalf}}/{slope}}-1}
	float expx = {exp {numx}}
	float numerator = {{rate}*{{V}-{vhalf}}}
	float entry = {{numerator}/{expx}}
	return {entry}
	// put in check for if v=vhalf then add 0.0001 or something. or... dtop/dbottom is L'Hopital.  
	
end

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