NMDAR & GABAB/KIR Give Bistable Dendrites: Working Memory & Sequence Readout (Sanders et al., 2013)

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Accession:169985
" ...Here, we show that the voltage dependence of the inwardly rectifying potassium (KIR) conductance activated by GABA(B) receptors adds substantial robustness to network simulations of bistability and the persistent firing that it underlies. The hyperpolarized state is robust because, at hyperpolarized potentials, the GABA(B)/KIR conductance is high and the NMDA conductance is low; the depolarized state is robust because, at depolarized potentials, the NMDA conductance is high and the GABA(B)/KIR conductance is low. Our results suggest that this complementary voltage dependence of GABA(B)/KIR and NMDA conductances makes them a "perfect couple" for producing voltage bistability."
References:
1 . Sanders H, Berends M, Major G, Goldman MS, Lisman JE (2013) NMDA and GABAB (KIR) conductances: the "perfect couple" for bistability. J Neurosci 33:424-9 [PubMed]
2 . Sanders H, Kolterman BE, Shusterman R, Rinberg D, Koulakov A, Lisman J (2014) A network that performs brute-force conversion of a temporal sequence to a spatial pattern: relevance to odor recognition. Front Comput Neurosci 8:108 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Hodgkin-Huxley neuron;
Channel(s): I K; I Na, leak; Kir;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: C or C++ program;
Model Concept(s): Working memory; Dendritic Bistability;
Implementer(s): Sanders, Honi [honi at brandeis.edu];
Search NeuronDB for information about:  GabaA; GabaB; AMPA; NMDA; I K; I Na, leak; Kir; Gaba; Glutamate;
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NMDA_network_modelDB
NMDA-GABAB_2013
Temporal-Spatial_2014
ReadMe.txt
turnx11
                            
#!/bin/bash
# in a gnuplot file that has a flag for whether to plot in x11 or something
# else, changes the flag to 1 or 0 depending on how it is called
# $1 is "on" or "off" for whether to set the flag on or off
# $2 is the name of the file to be changed

if [ $# -lt 2 ]; then
  echo "Correct syntax is \"turnx11 on|off filename\"" >&2
  exit 1
elif [ $1 = on ]; then
	newfile="$2a"
	sed 's/x11=0/x11=1/' < $2 > $newfile ; mv $newfile $2 ; chmod +x $2
elif [ $1 = off ]; then
	newfile="$2a"
	sed 's/x11=1/x11=0/' < $2 > $newfile ; mv $newfile $2 ; chmod +x $2
else
  echo "Correct syntax is \"turnx11 on|off filename\"" >&2 
fi

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