Early-onset epileptic encephalopathy (Miceli et al. 2015)

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Accession:170030
Model files from the paper "Early-Onset Epileptic Encephalopathy Caused by Gain-of-Function Mutations in the Voltage Sensor of Kv7.2 and Kv7.3 Potassium Channel Subunits" by Francesco Miceli, Maria Virginia Soldovieri, Paolo Ambrosino, Michela De Maria, Michele Migliore, Rosanna Migliore, and Maurizio Taglialatela J Neurosci. 2015 Mar 4;35(9):3782-93. The file fig7C.hoc reproduces the simulations shown in Fig.7C of the paper.
Reference:
1 . Miceli F, Soldovieri MV, Ambrosino P, De Maria M, Migliore M, Migliore R, Taglialatela M (2015) Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits. J Neurosci 35:3782-93 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I M; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Epilepsy;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,t; I A; I K; I M; I h; Glutamate;
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Kv72_ModelDB
readme.html
h.mod *
kadist.mod *
kamt.mod *
kaprox.mod *
kdrca1.mod *
ks.mod *
kv72wt73wt.mod *
kv72wt73wtR201C.mod
na3n.mod *
naxn.mod *
netstims.mod *
fig7C.hoc
fixnseg.hoc *
geo5038804-S.hoc
mosinit.hoc
olm-t.hoc
screenshot1.png
screenshot2.png
                            
TITLE CA1 KM channel from M. Taglialatela, Kv72wt+Kv72R201C+Kv73wt
: M. Migliore Oct 2014

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)

}

PARAMETER {
	v 		(mV)
	ek
	celsius 	(degC)
	gbar=.0001 	(mho/cm2)
        vhalfl=-43.4   	(mV)
		kl=-13.3
        vhalft=-67   	(mV)
        a0a=0.0035      	(/ms)
        zetat=5   	(1)
        gmt=.66   	(1)
        vhalfb=-73   	(mV)
        a0b=0.012      	(/ms)
        zetab=5    	(1)
        gmb=.9   	(1)
	q10=3.8
	b0=106
	b0b=30
	}


NEURON {
	SUFFIX kv72wt73wtR201C
	USEION k READ ek WRITE ik
        RANGE  gbar,ik
      GLOBAL inf, tau, taua, taub
}

STATE {
        m
}

ASSIGNED {
	ik (mA/cm2)
        inf
	tau
    taua
	taub
}

INITIAL {
	rate(v)
	m=inf
}


BREAKPOINT {
	SOLVE state METHOD cnexp
	ik = gbar*m*(v-ek)
}


FUNCTION alpa(v(mV)) {
  alpa = exp(0.0378*zetat*(v-vhalft)) 
}

FUNCTION alpb(v(mV)) {
  alpb = exp(0.0378*zetab*(v-vhalfb)) 
}


FUNCTION beta(v(mV)) {
  beta = exp(0.0378*zetat*gmt*(v-vhalft)) 
}

FUNCTION betb(v(mV)) {
  betb = exp(0.0378*zetab*gmb*(v-vhalfb)) 
}


DERIVATIVE state {
    rate(v)
    if (m<inf) {tau=taua} else {tau=taub}
	m' = (inf - m)/tau
}

PROCEDURE rate(v (mV)) { :callable from hoc
        LOCAL a,qt, ab, ac
        qt=q10^((celsius-22)/10)
        inf = (1/(1 + exp((v-vhalfl)/kl)))
        a = alpa(v)
        ab = alpb(v)
        taua = (b0 + beta(v)/(a0a*(1+a)))/qt
        taub = (b0b + betb(v)/(a0b*(1+ab)))/qt
}















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