Thalamic reticular neurons: the role of Ca currents (Destexhe et al 1996)

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Accession:17663
The experiments and modeling reported in this paper show how intrinsic bursting properties of RE cells may be explained by dendritic calcium currents.
Reference:
1 . Destexhe A, Contreras D, Steriade M, Sejnowski TJ, Huguenard JR (1996) In vivo, in vitro, and computational analysis of dendritic calcium currents in thalamic reticular neurons. J Neurosci 16:169-85 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus reticular nucleus cell;
Channel(s): I Na,t; I T low threshold; I K; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Bursting; Simplified Models; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr];
Search NeuronDB for information about:  Thalamus reticular nucleus cell; I Na,t; I T low threshold; I K; I Sodium; I Calcium; I Potassium;
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dendre
cells
README
capump.mod *
HH2.mod *
IT2.mod
VClamp.mod *
El.oc *
leak.oc *
loc3.oc *
loc80.oc *
locD.oc *
mosinit.hoc *
re1_cc.oc
re3_cc.oc
re3_vc.oc
re80_cc.oc
re80_vc.oc
reD_cc.oc
reD_vc.oc
rundemo.hoc *
                            
 NEURON TUTORIAL FOR IMPLEMENTING SIMULATIONS OF THALAMIC RETICULAR NEURONS

                          Alain Destexhe
		Laboratory for Computational Neuroscience
	Unit� de Neurosciences Int�gratives et Computationnelles (UNIC)
	Centre National de la Recherche Scientifique (CNRS)
			91198 Gif-sur-Yvette, France 

	    Formerly from (when this work was created):
            Department of Physiology, Laval University,
                      Quebec G1K 7P4, Canada

                       Destexhe@iaf.cnrs-gif.fr
                     http://cns.iaf.cnrs-gif.fr/Main.html


This package is running with the NEURON simulation program written by
Michael Hines and available on internet at:
  http://www.neuron.yale.edu/neuron/
  http://neuron.duke.edu/

The package contains mechanisms (.mod files) and programs (.oc files)
needed to simulate different models of thalamic reticular (RE)
neurons, relative to the paper:

  Destexhe A, Contreras D, Steriade M, Sejnowski TJ and Huguenard JR.
  In vivo, in vitro and computational analysis of dendritic calcium
  currents in thalamic reticular neurons.
  Journal of Neuroscience 16:  169-185, 1996.
  http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8613783&query_hl=7


A postscript version of this paper, including figures, is available on
internet at http://cns.iaf.cnrs-gif.fr/Main.html
  
  PROGRAMS
  ========

re1_cc.oc  : current clamp in one-compartment RE cell
re3_cc.oc  : current clamp in 3-compartment RE cell
re3_vc.oc  : voltage clamp in 3-compartment RE cell
re80_cc.oc : current clamp in 80-compartment RE cell
re80_vc.oc : voltage clamp in 80-compartment RE cell
reD_cc.oc  : current clamp in 8-compartment RE cell (dissociated cell)
reD_vc.oc  : voltage clamp in 8-compartment RE cell (dissociated cell)


  MECHANISMS
  ==========

 HH2.mod		: fast sodium spikes (Na and K currents)
 IT2.mod		: T-type calcium current of RE cells
 capump.mod		: intracellular calcium dynamics
 VClamp.mod		: mechanism for single-electrode voltage-clamp


  HOW TO RUN
  ==========

Use autolaunch on modeldb or:

unix platform:

  To compile the demo, NEURON and INTERVIEWS must be installed and
  working on the machine you are using.  Just type "nrnivmodl" to
  compile the mechanisms given in the mod files.

  Then, execute the main demo program by typing:

  nrngui mosinit.hoc

mswin platform:

  Compile the mechanism (mod) files by using mknrndll.  Then start the
  simulation by clicking on mosinit.hoc in windows explorer.

After either of the above platforms instructions: 

Once the menu and graphics interface has appeared, click on "Init and
Run" button or if appropriate ""Start protocol" for voltage clamp
families, to start the simulation...

For more information about how to get NEURON and how to install it,
please refer to the following sites:
  http://www.neuron.yale.edu/neuron/
  http://neuron.duke.edu/

For further information, please contact:

Alain Destexhe
Laboratory for Computational Neuroscience
Unit� de Neurosciences Int�gratives et Computationnelles (UNIC)
Centre National de la Recherche Scientifique (CNRS)
91198 Gif-sur-Yvette, France 

Destexhe@iaf.cnrs-gif.fr
http://cns.iaf.cnrs-gif.fr/Main.html

Updated 7/10/05 for button restart fix.
20120110 updated IT2.mod, capump.mod to replace euler with cnexp,
derivimplicit, respectively as per
http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592
and reformatted readme.

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