Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001)

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Accession:17664
We adopted De Schutter and Bower's model as the starting point, then modified the descriptions of several ion channels, such as the P-type Ca channel and the delayed rectifier K channel, and added class-E Ca channels and D-type K channels to the model. Our new model reproduces most of our experimental results and supports the conclusions of our experimental study that class-E Ca channels and D-type K channels are present and functioning in the dendrites of Purkinje neurons.
Reference:
1 . Miyasho T, Takagi H, Suzuki H, Watanabe S, Inoue M, Kudo Y, Miyakawa H (2001) Low-threshold potassium channels and a low-threshold calcium channel regulate Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling study. Brain Res 891:106-15 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Cerebellum purkinje cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; I_KD;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Bursting; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Action Potentials; Calcium dynamics;
Implementer(s): Miyakawa, H [Miyakawa at ls.toyaku.ac.jp];
Search NeuronDB for information about:  Cerebellum purkinje cell; I Na,p; I Na,t; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; I_KD;
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prknj
readme
CaE.mod *
CalciumP.mod *
CaP.mod *
CaP2.mod *
CaT.mod *
K2.mod *
K22.mod *
K23.mod *
KA.mod *
KC.mod *
KC2.mod *
KC3.mod *
KD.mod *
Kdr.mod *
Kh.mod *
Khh.mod *
KM.mod *
Leak.mod *
NaF.mod *
NaP.mod *
mosinit.hoc
purkinje.hoc
purkinje.ses
                            
Miyasho T, Takagi H, Suzuki H, Watanabe S, Inoue M, Kudo Y, Miyakawa H (2001) 
Low-threshold potassium channels and a low-threshold calcium channel regulate 
Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling 
study. 
Brain Res 891:106-115 

The mosinit.hoc file generates traces similar to figure 2 in the paper.
It takes about 5 minutes to generate this figure on a 800 MHz Win 2000 PC.

The model adopted De Schutter and Bower's model as the starting point, 
then modified the descriptions of several ion channels, such as the P-type 
Ca channel and the delayed rectifier K channel, and added class-E Ca 
channels and D-type K channels to the model. Our new model reproduces most
of our experimental results and supports the conclusions of our 
experimental study that class-E Ca channels and D-type K channels are 
present and functioning in the dendrites of Purkinje neurons.
See above paper for more details and references.

For more information on the model please contact Dr H. Miyakawa
email address: miyakawa@ls.toyaku.ac.jp

These model files were supplied by Dr. H. Miyakawa
20120110 CalciumP.mod updated solve method to derivimplicit as per
http://www.neuron.yale.edu/phpbb/viewtopic.php?f=28&t=592

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