Axon-somatic back-propagation in a detailed model of cat spinal motoneuron (Balbi et al, 2015)

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Accession:180370
Morphologically detailed conductance-based models of cat spinal alpha motoneurons have been developed, with the aim to reproduce and clarify some aspects of the electrophysiological behavior of the antidromic axon-somatic spike propagation. Fourteen 3D morphologically detailed somata and dendrites of cat spinal alpha motoneurons have been imported from an open-access web-based database of neuronal morphologies, NeuroMorpho.org, and instantiated in neurocomputational models.
Reference:
1 . Balbi P, Martinoia S, Massobrio P (2015) Axon-somatic back-propagation in detailed models of spinal alpha motoneurons. Front Comput Neurosci 9:15 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Spinal motoneuron;
Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell;
Channel(s): I Na,p; I Na,t; I K; I h; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s):
Implementer(s): Balbi, Pietro [piero.balbi at fsm.it];
Search NeuronDB for information about:  Spinal cord lumbar motor neuron alpha ACh cell; I Na,p; I Na,t; I K; I h; I K,Ca; I Calcium;
TITLE gh channel channel
: Hodgkin - Huxley h channel


NEURON {
	SUFFIX gh
	USEION k READ ek WRITE ik
	USEION na READ ena WRITE ina
	RANGE ghbar, ik, ina,htau, half, slp
	GLOBAL inf
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	v (mV)
	ghbar =.001 (mho/cm2) <0,1e9>
	htau = 50 (ms)
	half=-80 (mV)
	slp=8 (mV)
	ek = -77 (mV)
	ena = 50 (mV)
}
STATE {
	n
}
ASSIGNED {
	ik (mA/cm2)
	ina (mA/cm2)
	inf
}

INITIAL {
	rate(v)
	n = inf
}

BREAKPOINT {
	SOLVE states METHOD derivimplicit
	ik = 0.7*ghbar*n*(v - ek)
	ina = 0.3*ghbar*n*(v - ena)
}

DERIVATIVE states {	
	rate(v)
	n' = (inf - n)/htau
}
UNITSOFF

PROCEDURE rate(v(mV)) {	
	TABLE inf DEPEND half,slp FROM -100 TO 100 WITH 200
		inf = 1/(1+exp((v-half)/slp))
}
UNITSON

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