Alcohol action in a detailed Purkinje neuron model and an efficient simplified model (Forrest 2015)

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Accession:180789
" ... we employ a novel reduction algorithm to produce a 2 compartment model of the cerebellar Purkinje neuron from a previously published, 1089 compartment model. It runs more than 400 times faster and retains the electrical behavior of the full model. So, it is more suitable for inclusion in large network models, where computational power is a limiting issue. We show the utility of this reduced model by demonstrating that it can replicate the full model’s response to alcohol, which can in turn reproduce experimental recordings from Purkinje neurons following alcohol application. ..."
Reference:
1 . Forrest MD (2015) Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster BMC Neuroscience 16:27 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum purkinje cell;
Channel(s): I Na,t; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; I_HERG; Na/Ca exchanger; Na/K pump; I_AHP; I Cl, leak; I Na, leak; I Ca,p; I_KD; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Bursting; Ion Channel Kinetics; Oscillations; Simplified Models; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Sodium pump; Depolarization block; Dendritic Bistability;
Implementer(s): Forrest, Michael [mikeforrest at hotmail.com];
Search NeuronDB for information about:  Cerebellum purkinje cell; I Na,t; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; I_HERG; Na/Ca exchanger; Na/K pump; I_AHP; I Cl, leak; I Na, leak; I Ca,p; I_KD; Ca pump;
REFERENCE: Forrest MD (2015) Simulation of alcohol action upon a
detailed Purkinje neuron model and a simpler surrogate model that runs
>400 times faster. BMC Neuroscience

There are 2 seperate NEURON models here:

1) A Two compartment Purkinje cell model (reduced model, fast run
time)
2) A 1089 compartment Purkinje cell model (detailed model with
realistic morphology, slow run time)

To run the Two compartment model: Click on "mosinit_simple.hoc"
To run the 1089 compartment model: Click on "mosinit_full.hoc"

Both these models share and use the same .mod mechanisms. 

As an adside the NEURON code used to generate the reduced, Two
compartment model from the 1089 compartment model is included in the
folder called "collapse_algorithm"

Region: Cerebellum
Cell Type: Purkinje cell
Simulator: NEURON 
Topics: Activity Patterns, Bursting, Oscillations, Active Dendrites,
Calcium dynamics, Depolarisation block, Detailed Neurnal Models,
Sodium pump, Simplified Models, Influence of Dendritic Geometry

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