Alcohol action in a detailed Purkinje neuron model and an efficient simplified model (Forrest 2015)

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Accession:180789
" ... we employ a novel reduction algorithm to produce a 2 compartment model of the cerebellar Purkinje neuron from a previously published, 1089 compartment model. It runs more than 400 times faster and retains the electrical behavior of the full model. So, it is more suitable for inclusion in large network models, where computational power is a limiting issue. We show the utility of this reduced model by demonstrating that it can replicate the full model’s response to alcohol, which can in turn reproduce experimental recordings from Purkinje neurons following alcohol application. ..."
Reference:
1 . Forrest MD (2015) Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster BMC Neuroscience 16:27 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum purkinje cell;
Channel(s): I Na,t; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; I_HERG; Na/Ca exchanger; Na/K pump; I_AHP; I Cl, leak; I Na, leak; I Ca,p; I_KD; Ca pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Bursting; Ion Channel Kinetics; Oscillations; Simplified Models; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Sodium pump; Depolarization block; Dendritic Bistability;
Implementer(s): Forrest, Michael [mikeforrest at hotmail.com];
Search NeuronDB for information about:  Cerebellum purkinje cell; I Na,t; I T low threshold; I A; I K; I K,leak; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; I_HERG; Na/Ca exchanger; Na/K pump; I_AHP; I Cl, leak; I Na, leak; I Ca,p; I_KD; Ca pump;
REFERENCE: Forrest MD (2015) Simulation of alcohol action upon a
detailed Purkinje neuron model and a simpler surrogate model that runs
>400 times faster. BMC Neuroscience

There are 2 seperate NEURON models here:

1) A Two compartment Purkinje cell model (reduced model, fast run
time)
2) A 1089 compartment Purkinje cell model (detailed model with
realistic morphology, slow run time)

To run the Two compartment model: Click on "mosinit_simple.hoc"
To run the 1089 compartment model: Click on "mosinit_full.hoc"

Both these models share and use the same .mod mechanisms. 

As an adside the NEURON code used to generate the reduced, Two
compartment model from the 1089 compartment model is included in the
folder called "collapse_algorithm"

Region: Cerebellum
Cell Type: Purkinje cell
Simulator: NEURON 
Topics: Activity Patterns, Bursting, Oscillations, Active Dendrites,
Calcium dynamics, Depolarisation block, Detailed Neurnal Models,
Sodium pump, Simplified Models, Influence of Dendritic Geometry

Forrest MD (2015) Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster BMC Neuroscience 16:27[PubMed]

References and models cited by this paper

References and models that cite this paper

Crystal structure of the sodium-potassium pump. Nature 450:1043-9 [PubMed]

Akemann W, Knopfel T (2006) Interaction of Kv3 potassium channels and resurgent sodium current influences the rate of spontaneous firing of Purkinje neurons. J Neurosci 26:4602-12 [Journal] [PubMed]

   Cerebellar purkinje cell: interacting Kv3 and Na currents influence firing (Akemann, Knopfel 2006) [Model]

Albus JS (1971) A theory of cerebellar function Math Biosci 10:25-61

Appel SB, Liu Z, McElvain MA, Brodie MS (2003) Ethanol excitation of dopaminergic ventral tegmental area neurons is blocked by quinidine. J Pharmacol Exp Ther 306:437-46 [PubMed]

Benton MD, Lewis AH, Bant JS, Raman IM (2013) Iberiotoxin-sensitive and-insensitive BK currents in Purkinje neuron somata. J Neurophysiol 109:2528-41 [PubMed]

Bloom FE, Siggins GR (2007) Electrophysiological action of ethanol at the cellular level. Alcohol 4:331-7 [PubMed]

Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2010) Alcohol excites cerebellar Golgi cells by inhibiting the Na(+)-K(+) ATPase. Neuropsychopharmacology 35:1984-96 [Journal] [PubMed]

   Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010) [Model]

Botta P, Simões de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2012) Excitation of rat cerebellar Golgi cells by ethanol: further characterization of the mechanism. Alcohol Clin Exp Res 36:616-24 [PubMed]

Bower JM (2013) The emergence of community models in computational neuroscience: The 40-Year history of the cerebellar Purkinje cell. 20 years of computational neuroscience :103-140

Brodie MS, Appel SB (1998) The effects of ethanol on dopaminergic neurons of the ventral tegmental area studied with intracellular recording in brain slices. Alcohol Clin Exp Res 22:236-44 [PubMed]

Brodie MS, Scholz A, Weiger TM, Dopico AM (2007) Ethanol interactions with calcium-dependent potassium channels. Alcohol Clin Exp Res 31:1625-32 [PubMed]

Bush PC, Sejnowski TJ (1993) Reduced compartmental models of neocortical pyramidal cells. J Neurosci Methods 46:159-66 [PubMed]

Canavier CC, Oprisan SA, Callaway JC, Ji H, Shepard PD (2007) Computational Model Predicts a Role for ERG Current in Repolarizing Plateau Potentials in Dopamine Neurons: Implications for Modulation of Neuronal Activity. J Neurophysiol 98:3006-3022 [Journal] [PubMed]

   ERG current in repolarizing plateau potentials in dopamine neurons (Canavier et al 2007) [Model]

Carnevale NT, Hines ML (2006) The NEURON Book

Chen X, Kovalchuk Y, Adelsberger H, Henning HA, Sausbier M, Wietzorrek G, Ruth P, Yarom Y, Ko (2010) Disruption of the olivo-cerebellar circuit by Purkinje neuron-specific ablation of BK channels. Proc Natl Acad Sci U S A 107:12323-8 [PubMed]

Covarrubias M, Rubin E (1993) Ethanol selectively blocks a noninactivating K+ current expressed in Xenopus oocytes. Proc Natl Acad Sci U S A 90:6957-60 [PubMed]

De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell. I. Simulation of current clamps in slice. J Neurophysiol 71:375-400 [Journal] [PubMed]

   Cerebellar purkinje cell (De Schutter and Bower 1994) [Model]

De Schutter E, Bower JM (1994) An active membrane model of the cerebellar Purkinje cell II. Simulation of synaptic responses. J Neurophysiol 71:401-19 [Journal] [PubMed]

   Cerebellar purkinje cell (De Schutter and Bower 1994) [Model]

Destexhe A, Neubig M, Ulrich D, Huguenard J (1998) Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci 18:3574-88 [Journal] [PubMed]

   [2 reconstructed morphologies on NeuroMorpho.Org]
   Low Threshold Calcium Currents in TC cells (Destexhe et al 1998) [Model]

Diaz MR, Wadleigh A, Kumar S, De Schutter E, Valenzuela CF (2013) Na+-K+-ATPase inhibition partially mimics the ethanol-induced increase of the Golgi cell-dependent component of the tonic GABAergic current in rat cerebellar granule cells. PLoS One 8:e55673-24 [PubMed]

Dopico AM, Lemos JR, Treistman SN (1996) Ethanol increases the activity of large conductance, Ca(2+)-activated K+ channels in isolated neurohypophysial terminals. Mol Pharmacol 49:40-8 [PubMed]

Edgerton JR, Reinhart PH (2003) Distinct contributions of small and large conductance Ca2+-activated K+ channels to rat Purkinje neuron function. J Physiol 548:53-69 [PubMed]

Engbers JD, Anderson D, Asmara H, Rehak R, Mehaffey WH, Hameed S, McKay BE, Kruskic M, Zampon (2012) Intermediate conductance calcium-activated potassium channels modulate summation of parallel fiber input in cerebellar Purkinje cells. Proc Natl Acad Sci U S A 109:2601-6 [PubMed]

Forrest MD (2008) The biophysics of Purkinje computation Ph.D. Thesis, University of Warwick

Forrest MD (2013) Mathematical model of bursting in dissociated purkinje neurons. PLoS One 8:e68765-71 [PubMed]

Forrest MD (2014) Intracellular calcium dynamics permit a Purkinje neuron model to perform toggle and gain computations upon its inputs. Front Comput Neurosci 8:86-71 [PubMed]

Forrest MD (2014) Biophysics and computations of the cerebellar Purkinje neuron Seattle, Createspace

Forrest MD, Wall MJ, Press DA (2009) The sodium-potassium pump controls the intrinsic g of the cerebellar Purkinje neuron Poster session presented at: ICONIP 2009; 16th 1136 International Conference on Neural Information Processing Bangkok, Thailand

Forrest MD, Wall MJ, Press DA, Feng J (2012) The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. PLoS One 7:e51169 [PubMed]

Galindo R, Zamudio PA, Valenzuela CF (2005) Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder. J Neurochem 94:1500-11 [PubMed]

Genet S, Kado RT (1997) Hyperpolarizing current of the Na-K ATPase contributes to the membrane polarization of the Purkinje cell in rat cerebellum. Pflugers Arch 434:559-67 [PubMed]

Getting PA (1989) Emerging principles governing the operation of neural networks. Annu Rev Neurosci 12:185-204 [PubMed]

Glitsch HG (2001) Electrophysiology of the sodium-potassium-ATPase in cardiac cells. Physiol Rev 81:1791-826 [PubMed]

Habuchi Y, Furukawa T, Tanaka H, Lu LL, Morikawa J, Yoshimura M (1995) Ethanol inhibition of Ca2+ and Na+ currents in the guinea-pig heart. Eur J Pharmacol 292:143-9 [PubMed]

Hanslick JL, Lau K, Noguchi KK, Olney JW, Zorumski CF, Mennerick S, Farber NB (2009) Dimethyl sulfoxide (DMSO) produces widespread apoptosis in the developing central nervous system. Neurobiol Dis 34:1-10 [PubMed]

Haviv H, Habeck M, Kanai R, Toyoshima C, Karlish SJ (2013) Neutral phospholipids stimulate Na,K-ATPase activity: a specific lipid-protein interaction. J Biol Chem 288:10073-81 [PubMed]

Hille B (2001) Ionic Channels of Excitable Membranes

Hines M, Eichner H, Schuermann F (2008) Neuron splitting in compute-bound parallel network simulations enables runtime scaling with twice as many processors J Comput Neurosci 25(1):203-210 [Journal] [PubMed]

   Cell splitting in neural networks extends strong scaling (Hines et al. 2008) [Model]

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Hines ML, Markram H, Schuermann F (2008) Fully Implicit Parallel Simulation of Single Neurons J Comp Neurosci 25:439-448 [Journal] [PubMed]

   Fully Implicit Parallel Simulation of Single Neurons (Hines et al. 2008) [Model]

Hines ML, Morse T, Migliore M, Carnevale NT, Shepherd GM (2004) ModelDB: A Database to Support Computational Neuroscience. J Comput Neurosci 17:7-11 [Journal] [PubMed]

Hirono M, Yamada M, Obata K (2009) Ethanol enhances both action potential-dependent and action potential-independent GABAergic transmission onto cerebellar Purkinje cells. Neuropharmacology 57:109-20 [PubMed]

Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-44 [Journal] [PubMed]

   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

Horishita T, Harris RA (2008) n-Alcohols inhibit voltage-gated Na+ channels expressed in Xenopus oocytes. J Pharmacol Exp Ther 326:270-7 [PubMed]

Israel Y, Kalant H, Laufer I (1965) Effects of ethanol on na, K, mg-stimulated microsomal ATPase activity. Biochem Pharmacol 14:1803-14 [PubMed]

Ito M (2006) Cerebellar circuitry as a neuronal machine. Prog Neurobiol 78:272-303 [PubMed]

Kanai R, Ogawa H, Vilsen B, Cornelius F, Toyoshima C (2013) Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state. Nature 502:201-6 [PubMed]

Khaliq ZM, Gouwens NW, Raman IM (2003) The contribution of resurgent sodium current to high-frequency firing in Purkinje neurons: an experimental and modeling study. J Neurosci 23:4899-912 [PubMed]

   Cerebellar Purkinje Cell: resurgent Na current and high frequency firing (Khaliq et al 2003) [Model]

Klein G, Gardiwal A, Schaefer A, Panning B, Breitmeier D (2007) Effect of ethanol on cardiac single sodium channel gating. Forensic Sci Int 171:131-5 [PubMed]

Komendantov AO, Komendantova OG, Johnson SW, Canavier CC (2004) A modeling study suggests complementary roles for GABAA and NMDA receptors and the SK channel in regulating the firing pattern in midbrain dopamine neurons. J Neurophysiol 91:346-57 [Journal] [PubMed]

   Regulation of the firing pattern in dopamine neurons (Komendantov et al 2004) [Model]

Koyama S, Brodie MS, Appel SB (2007) Ethanol inhibition of m-current and ethanol-induced direct excitation of ventral tegmental area dopamine neurons. J Neurophysiol 97:1977-85 [PubMed]

Lapine M, Shadrivov I, Kivshar Y (2012) Wide-band negative permeability of nonlinear metamaterials. Sci Rep 2:1-4 [PubMed]

Laursen M, Yatime L, Nissen P, Fedosova NU (2013) Crystal structure of the high-affinity Na+K+-ATPase-ouabain complex with Mg2+ bound in the cation binding site. Proc Natl Acad Sci U S A 110:10958-63 [PubMed]

Ledig M, Kopp P, Mandel P (1985) Effect of ethanol on adenosine triphosphatase and enolase activities in rat brain and in cultured nerve cells. Neurochem Res 10:1311-24 [PubMed]

Lein ES, Hawrylycz MJ, Ao N, Ayres M, Bensinger A, Bernard A, Boe AF, Boguski MS, Brockway KS (2007) Genome-wide atlas of gene expression in the adult mouse brain. Nature 445:168-76 [PubMed]

Li KC, Zhang FX, Li CL, Wang F, Yu MY, Zhong YQ, Zhang KH, Lu YJ, Wang Q, Ma XL, Yao JR, Wang (2011) Follistatin-like 1 suppresses sensory afferent transmission by activating Na+,K+-ATPase. Neuron 69:974-87

Liu J, Asuncion-Chin M, Liu P, Dopico AM (2006) CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels. Nat Neurosci 9:41-9 [PubMed]

Liu J, Vaithianathan T, Manivannan K, Parrill A, Dopico AM (2008) Ethanol modulates BKCa channels by acting as an adjuvant of calcium. Mol Pharmacol 74:628-40 [PubMed]

Lupica CR, Brodie MS (2006) Queer currents, steady rhythms, and drunken da neurons. Focus on "hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice". J Neurophysiol 95:585-6 [PubMed]

Marasco A, Limongiello A, Migliore M (2013) Using Strahler`s analysis to reduce up to 200-fold the run time of realistic neuron model Sci. Rep. 3:2934 [Journal] [PubMed]

   Using Strahler`s analysis to reduce realistic models (Marasco et al, 2013) [Model]

Marder E (2011) Variability, compensation, and modulation in neurons and circuits. Proc Natl Acad Sci U S A 108 Suppl 3:15542-8 [PubMed]

Markram H (2006) The blue brain project. Nat Rev Neurosci 7:153-60 [Journal] [PubMed]

   [241 reconstructed morphologies on NeuroMorpho.Org]

Marr D (1969) A theory of cerebellar cortex. J Physiol 202:437-70 [PubMed]

Martina M, Yao GL, Bean BP (2003) Properties and functional role of voltage-dependent potassium channels in dendrites of rat cerebellar Purkinje neurons. J Neurosci 23:5698-707 [PubMed]

McKay BE, Engbers JD, Mehaffey WH, Gordon GR, Molineux ML, Bains JS, Turner RW (2007) Climbing fiber discharge regulates cerebellar functions by controlling the intrinsic characteristics of purkinje cell output. J Neurophysiol 97:2590-604

McKay BE, Turner RW (2004) Kv3 K+ channels enable burst output in rat cerebellar Purkinje cells. Eur J Neurosci 20:729-39 [PubMed]

McKay BE, Turner RW (2005) Physiological and morphological development of the rat cerebellar Purkinje cell. J Physiol 567:829-50 [PubMed]

Mereu G, Fadda F, Gessa GL (1984) Ethanol stimulates the firing rate of nigral dopaminergic neurons in unanesthetized rats. Brain Res 292:63-9 [PubMed]

Miyasho T, Takagi H, Suzuki H, Watanabe S, Inoue M, Kudo Y, Miyakawa H (2001) Low-threshold potassium channels and a low-threshold calcium channel regulate Ca2+ spike firing in the dendrites of cerebellar Purkinje neurons: a modeling study. Brain Res 891:106-15 [Journal] [PubMed]

   Cerebellar purkinje cell: K and Ca channels regulate APs (Miyasho et al 2001) [Model]

Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandl (2009) Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. Alcohol Clin Exp Res 33:1125-35 [PubMed]

Nathanson JA, Scavone C, Scanlon C, McKee M (1995) The cellular Na+ pump as a site of action for carbon monoxide and glutamate: a mechanism for long-term modulation of cellular activity. Neuron 14:781-94

Nerbonne JM, Gerber BR, Norris A, Burkhalter A (2008) Electrical remodelling maintains firing properties in cortical pyramidal neurons lacking KCND2-encoded A-type K+ currents. J Physiol 586:1565-79

Nyblom M, Poulsen H, Gourdon P, Reinhard L, Andersson M, Lindahl E, Fedosova N, Nissen P (2013) Crystal structure of Na+, K(+)-ATPase in the Na(+)-bound state. Science 342:123-7 [PubMed]

Okamoto T, Harnett MT, Morikawa H (2006) Hyperpolarization-activated cation current (Ih) is an ethanol target in midbrain dopamine neurons of mice. J Neurophysiol 95:619-26 [PubMed]

Peng L, Martin-Vasallo P, Sweadner KJ (1997) Isoforms of Na,K-ATPase alpha and beta subunits in the rat cerebellum and in granule cell cultures. J Neurosci 17:3488-502 [PubMed]

Philipson KD (1985) Sodium-calcium exchange in plasma membrane vesicles. Annu Rev Physiol 47:561-71 [PubMed]

Pinsky PF, Rinzel J (1994) Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 1:39-60 [Journal] [PubMed]

   CA3 pyramidal cell: rhythmogenesis in a reduced Traub model (Pinsky, Rinzel 1994) [Model]

Prinz A (2006) Neuronal parameter optimization Scholarpedia 2(1):1903

RALL W (1959) Branching dendritic trees and motoneuron membrane resistivity. Exp Neurol 1:491-527 [PubMed]

Rall W (1989) Cable theory for dendritic neurons Methods In Neuronal Modeling: From Synapses To Networks, Koch C:Segev I, ed. pp.9

Raman IM, Bean BP (2001) Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophys J 80:729-37 [PubMed]

   Cerebellar Purkinje Cell: resurgent Na current and high frequency firing (Khaliq et al 2003) [Model]

Rangaraj N, Kalant H (1982) Effect of chronic ethanol treatment on temperature dependence and on norepinephrine sensitization of rat brain (Na+ + K+)-adenosine triphosphatase. J Pharmacol Exp Ther 223:536-9 [PubMed]

Rapp M, Segev I, Yarom Y (1994) Physiology, morphology and detailed passive models of guinea-pig cerebellar Purkinje cells. J Physiol 474:101-18 [PubMed]

   [3 reconstructed morphologies on NeuroMorpho.Org]

Rapp M, Yarom Y, Segev I (1992) The impact of parallel fiber background activity on the cable properties of cerebellar Purkinje cells Neural Comput 4:518-533

Rogers J, Madamba SG, Staunton DA, Siggins GR (1986) Ethanol increases single unit activity in the inferior olivary nucleus. Brain Res 385:253-62 [PubMed]

Sacco T, Bruno A, Wanke E, Tempia F (2003) Functional roles of an ERG current isolated in cerebellar Purkinje neurons. J Neurophysiol 90:1817-28 [PubMed]

Sanguinetti MC, Tristani-Firouzi M (2006) hERG potassium channels and cardiac arrhythmia. Nature 440:463-9 [PubMed]

Saraga F, Wu CP, Zhang L, Skinner FK (2003) Active Dendrites and Spike Propagation in Multi-compartment Models of Oriens-Lacunosum/Moleculare Hippocampal Interneurons. J Physiol 552(3):673-689 [Journal] [PubMed]

   Active dendrites and spike propagation in a hippocampal interneuron (Saraga et al 2003) [Model]

Sausbier M, Hu H, Arntz C, Feil S, Kamm S, Adelsberger H, Sausbier U, Sailer CA, Feil R, Hofm (2004) Cerebellar ataxia and Purkinje cell dysfunction caused by Ca2+-activated K+ channel deficiency. Proc Natl Acad Sci U S A 101:9474-8 [PubMed]

Schmahmann JD (2004) Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci 16:367-78 [PubMed]

Seo WS, Suh CK (2001) Acute effect of ethanol on firing patterns of Purkinje cells in the rat cerebellar slice preparation. Yonsei Med J 42:384-9 [PubMed]

Shelton DP (1985) Membrane resistivity estimated for the Purkinje neuron by means of a passive computer model. Neuroscience 14:111-31 [PubMed]

Shinoda T, Ogawa H, Cornelius F, Toyoshima C (2009) Crystal structure of the sodium-potassium pump at 2.4 A resolution. Nature 459:446-50 [PubMed]

Sivagnanam S,Majumdar A, Yoshimoto K, Astakhov V, Bandrowski A, Martone ME, Carnevale NT (2013) Introducing the Neuroscience Gateway 2013 IWSG, volume 993 of CEUR Workshop Proceedings, CEUR-WS.org, [Journal]

Swann AC (1983) Brain (Na+,K+)-ATPase. Opposite effects of ethanol and dimethyl sulfoxide on temperature dependence of enzyme conformation and univalent cation binding. J Biol Chem 258:11780-6 [PubMed]

Syapin PJ, Alkana RL (1986) Ethanol-induced inhibition of mouse brain adenosine triphosphatase activities: lack of interaction with norepinephrine in vitro. Alcohol Clin Exp Res 10:635-40 [PubMed]

Syapin PJ, Chen J, Alkana RL (2007) Effect of norepinephrine on inhibition of mouse brain (Na+ + K+)-stimulated, (Mg++)-dependent, and (Ca++)-dependent ATPase activities by ethanol. Alcohol 2:145-8 [PubMed]

Takeuchi A, Reyes N, Artigas P, Gadsby DC (2008) The ion pathway through the opened Na(+),K(+)-ATPase pump. Nature 456:413-6

Tesche CD, Karhu JJ (2000) Anticipatory cerebellar responses during somatosensory omission in man. Hum Brain Mapp 9:119-42 [PubMed]

Vandenberg JI, Perry MD, Perrin MJ, Mann SA, Ke Y, Hill AP (2012) hERG K(+) channels: structure, function, and clinical significance. Physiol Rev 92:1393-478 [PubMed]

Verma A, Hirsch DJ, Glatt CE, Ronnett GV, Snyder SH (1993) Carbon monoxide: a putative neural messenger. Science 259:381-4 [PubMed]

Womack M, Khodakhah K (2002) Active contribution of dendrites to the tonic and trimodal patterns of activity in cerebellar Purkinje neurons. J Neurosci 22:10603-12 [PubMed]

Womack MD, Chevez C, Khodakhah K (2004) Calcium-activated potassium channels are selectively coupled to P-Q-type calcium channels in cerebellar Purkinje neurons. J Neurosci 24:8818-22 [PubMed]

Womack MD, Hoang C, Khodakhah K (2009) Large conductance calcium-activated potassium channels affect both spontaneous firing and intracellular calcium concentration in cerebellar Purkinje neurons. Neuroscience 162:989-1000 [PubMed]

Womack MD, Khodakhah K (2003) Somatic and dendritic small-conductance calcium-activated potassium channels regulate the output of cerebellar purkinje neurons. J Neurosci 23:2600-7 [PubMed]

Womack MD, Khodakhah K (2004) Dendritic control of spontaneous bursting in cerebellar Purkinje cells. J Neurosci 24:3511-21 [PubMed]

Xiao Z, Lu Z, Liu Z, Liu W, Li L, Yin S, Yu S, Dong H, Zhu F (2008) Ethanol inhibits voltage-gated sodium channels in cultured superior cervical ganglion neurons. Neuroreport 19:1773-6 [PubMed]

Yan H, Li Q, Fleming R, Madison RD, Wilson WA, Swartzwelder HS (2009) Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih. J Neurophysiol 101:67-83

Zagha E, Manita S, Ross WN, Rudy B (2010) Dendritic Kv3.3 potassium channels in cerebellar purkinje cells regulate generation and spatial dynamics of dendritic Ca2+ spikes. J Neurophysiol 103:3516-25 [PubMed]

(109 refs)