Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)

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Accession:181967
"A recent experimental study (Mizuseki et al., 2009) has shown that the temporal delays between population activities in successive entorhinal and hippocampal anatomical stages are longer (about 70–80 ms) than expected from axon conduction velocities and passive synaptic integration of feed-forward excitatory inputs. We investigate via computer simulations the mechanisms that give rise to such long temporal delays in the hippocampus structures. ... The model shows that the experimentally reported long temporal delays in the DG, CA3 and CA1 hippocampal regions are due to theta modulated somatic and axonic inhibition..."
Reference:
1 . Cutsuridis V, Poirazi P (2015) A computational study on how theta modulated inhibition can account for the long temporal windows in the entorhinal-hippocampal loop. Neurobiol Learn Mem 120:69-83 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule GLU cell; Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell; Hippocampus CA1 basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA3 axo-axonic cells;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Pattern Recognition; Temporal Pattern Generation; Spatio-temporal Activity Patterns; Brain Rhythms; Storage/recall;
Implementer(s): Cutsuridis, Vassilis [vcutsuridis at gmail.com];
Search NeuronDB for information about:  Dentate gyrus granule GLU cell; Hippocampus CA1 pyramidal GLU cell; Hippocampus CA3 pyramidal GLU cell; Hippocampus CA3 interneuron basket GABA cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP;
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CutsuridisPoirazi2015
Results
Weights
readme.html
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// Data from Saraga et al. (2003) paper
//   OLM_Cell

begintemplate OLMCell
public is_art
public init, topol, basic_shape, subsets, geom, biophys, geom_nseg
public pre_list, connect2target

public soma, dend1, dend2, axon
public all

objref pre_list

proc init() {
  	topol()
  	subsets()
  	geom()
  	biophys()
  	geom_nseg()
  	pre_list = new List()
  	synapses()
  
}

create soma, dend1, dend2, axon

proc topol() { local i
  	connect dend1(0), soma(1)
  	connect dend2(0), soma(0)
  	connect axon(0), soma(1)
  	basic_shape()
}

proc basic_shape() {
  	soma {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(15, 0, 0, 1)}
  	dend1 {pt3dclear() pt3dadd(15, 0, 0, 1) pt3dadd(90, 0, 0, 1)}
  	dend2 {pt3dclear() pt3dadd(0, 0, 0, 1) pt3dadd(-74, 0, 0, 1)}
  	axon {pt3dclear() pt3dadd(15, 0, 0, 1) pt3dadd(15, 120, 0, 1)}
}

objref all
proc subsets() { local i
  	objref all
  	all = new SectionList()
    	soma all.append()
    	dend1 all.append()
    	dend2 all.append()
    	axon all.append()

}

proc geom() {
  	forsec all {  }
  	soma {  L = 20  diam = 10  }
  	dend1 {  L = 250  diam = 3  }
  	dend2 {  L = 250  diam = 3  }
  	axon {  L = 150  diam = 1.5  }
}

external lambda_f
proc geom_nseg() {
  forsec all { nseg = int((L/(0.1*lambda_f(100))+.9)/2)*2 + 1  }
}

proc biophys() {

	Rm = 20000
	//Rm = 1/5e-05		// original
	
  	forsec all {
  		Ra = 150
    		cm = 1.3
  	}
  	soma {
		insert IA
		gkAbar_IA = 0.0165
		insert Ih
		gkhbar_Ih = 0.0005
//		gkhbar_Ih = 0.001385
		insert Ksoma
		gksoma_Ksoma = 0.0319
		insert Nasoma
		gnasoma_Nasoma = 0.0107
		gl_Nasoma = 1/Rm
		el_Nasoma = -70  	
	}
  
  	dend1 {
		insert IA
    		gkAbar_IA = 0.004
     		//gkAbar_IA = 0.013
		//insert Ih
		//gkhbar_Ih = 0.001385
		insert Kdend
		gkdend_Kdend = 0.033//2*0.023
		insert Nadend
		gnadend_Nadend = 0.0127//2*0.0117
		gl_Nadend = 1/Rm
		el_Nadend = -70
  	}
  
  	dend2 {
		insert IA
    		gkAbar_IA = 0.004
    		//gkAbar_IA = 0.013
		//insert Ih
		//gkhbar_Ih = 0.001385
		insert Kdend
		gkdend_Kdend = 0.033//2*0.023
		insert Nadend
		gnadend_Nadend = 0.0127//2*0.0117
		gl_Nadend = 1/Rm
		el_Nadend = -70
  	}
  
  	axon {
		insert Kaxon
		gkaxon_Kaxon = 0.05104
		insert Naaxon
		gnaaxon_Naaxon = 0.01712
		gl_Naaxon = 1/Rm
		el_Naaxon = -70

  	}
}

obfunc connect2target() { localobj nc //$o1 target point process, optional $o2 returned NetCon
  	soma nc = new NetCon(&v(1), $o1)
  	nc.threshold = -10
  	if (numarg() == 2) { $o2 = nc } // for backward compatibility
  	return nc
}

objref syn_
proc synapses() {
  	/* E0 */   dend2 syn_ = new Exp2Syn(0.5)  pre_list.append(syn_)		// AMPA		PC
    	syn_.tau1 = 0.5
    	syn_.tau2 = 3
  	/* E1 */   dend1 syn_ = new Exp2Syn(0.5)  pre_list.append(syn_)		// AMPA		PC
    	syn_.tau1 = 0.5
    	syn_.tau2 = 3
  	/* I2 */   soma syn_ = new Exp2Syn(0.5)  pre_list.append(syn_)		// GABA-A	Septum
    	syn_.tau1 = 1
    	syn_.tau2 = 8
    	syn_.e = -75
  	/* I3 */   soma syn_ = new Exp2Syn(0.5)  pre_list.append(syn_)		// GABA-B	Septum
    	syn_.tau1 = 35
    	syn_.tau2 = 100
    	syn_.e = -75
}

func is_art() { return 0 }

endtemplate OLMCell


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