Long time windows from theta modulated inhib. in entorhinal–hippo. loop (Cutsuridis & Poirazi 2015)

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Accession:181967
"A recent experimental study (Mizuseki et al., 2009) has shown that the temporal delays between population activities in successive entorhinal and hippocampal anatomical stages are longer (about 70–80 ms) than expected from axon conduction velocities and passive synaptic integration of feed-forward excitatory inputs. We investigate via computer simulations the mechanisms that give rise to such long temporal delays in the hippocampus structures. ... The model shows that the experimentally reported long temporal delays in the DG, CA3 and CA1 hippocampal regions are due to theta modulated somatic and axonic inhibition..."
Reference:
1 . Cutsuridis V, Poirazi P (2015) A computational study on how theta modulated inhibition can account for the long temporal windows in the entorhinal-hippocampal loop. Neurobiol Learn Mem 120:69-83 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule cell; Hippocampus CA1 pyramidal cell; Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell; Hippocampus CA1 basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron; Hippocampus CA1 bistratified cell; Hippocampus CA1 axo-axonic cell; Hippocampus CA3 axo-axonic cells;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Pattern Recognition; Temporal Pattern Generation; Spatio-temporal Activity Patterns; Brain Rhythms; Storage/recall;
Implementer(s): Cutsuridis, Vassilis [vcutsuridis at gmail.com];
Search NeuronDB for information about:  Dentate gyrus granule cell; Hippocampus CA1 pyramidal cell; Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP;
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CutsuridisPoirazi2015
Results
Weights
readme.html
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TITLE decay of internal calcium concentration
:
: Internal calcium concentration due to calcium currents and pump.
: Differential equations.
:
: Simple model of ATPase pump with 3 kinetic constants (Destexhe 92)
:     Cai + P <-> CaP -> Cao + P  (k1,k2,k3)
: A Michaelis-Menten approximation is assumed, which reduces the complexity
: of the system to 2 parameters: 
:       kt = <tot enzyme concentration> * k3  -> TIME CONSTANT OF THE PUMP
:	kd = k2/k1 (dissociation constant)    -> EQUILIBRIUM CALCIUM VALUE
: The values of these parameters are chosen assuming a high affinity of 
: the pump to calcium and a low transport capacity (cfr. Blaustein, 
: TINS, 11: 438, 1988, and references therein).  
:
: Units checked using "modlunit" -> factor 10000 needed in ca entry
:
: VERSION OF PUMP + DECAY (decay can be viewed as simplified buffering)
:
: All variables are range variables
:
:
: This mechanism was published in:  Destexhe, A. Babloyantz, A. and 
: Sejnowski, TJ.  Ionic mechanisms for intrinsic slow oscillations in
: thalamic relay neurons. Biophys. J. 65: 1538-1552, 1993)
:
: Written by Alain Destexhe, Salk Institute, Nov 12, 1992
:
: This file was modified by Yiota Poirazi (poirazi@LNC.usc.edu) on April 18, 2001 to account for the sharp
: Ca++ spike repolarization observed in: Golding, N. Jung H-Y., Mickus T. and Spruston N
: "Dendritic Calcium Spike Initiation and Repolarization are controlled by distinct potassium channel
: subtypes in CA1 pyramidal neurons". J. of Neuroscience 19(20) 8789-8798, 1999.
:
:  factor 10000 is replaced by 10000/18 needed in ca entry
:  taur --rate of calcium removal-- is replaced by taur*7 (7 times faster)
:
: 20150524 NTC
: Fixed ca initialization by inserting cai = ca into INITIAL block.
: Changed integration method from euler to derivimplicit
: which is appropriate for simple ion accumulation mechanisms.
: See
: Integration methods for SOLVE statements
: http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592

NEURON {
	SUFFIX cad
	USEION ca READ ica, cai WRITE cai	
        RANGE ca
	GLOBAL depth,cainf,taur
}

UNITS {
	(molar) = (1/liter)			: moles do not appear in units
	(mM)	= (millimolar)
	(um)	= (micron)
	(mA)	= (milliamp)
	(msM)	= (ms mM)
	FARADAY = (faraday) (coulomb)
}


PARAMETER {
	depth	= 0.1	(um)		: depth of shell
	taur	= 200	(ms)		: rate of calcium removal
	cainf	= 100e-6(mM)
	cai		(mM)
}

STATE {
	ca		(mM) 
}

INITIAL {
	ca = cainf
  cai = ca
}

ASSIGNED {
	ica		(mA/cm2)
	drive_channel	(mM/ms)
}
	
BREAKPOINT {
	SOLVE state METHOD derivimplicit : not euler
    : see http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
}

DERIVATIVE state { 

	drive_channel =  - (10000) * ica / (2 * FARADAY * depth)
	if (drive_channel <= 0.) { drive_channel = 0.  }   : cannot pump inward 
         
	:ca' = drive_channel + (cainf-ca)/taur
        ca' = drive_channel/18 + (cainf -ca)/taur*7
	cai = ca
}


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