Cortical model with reinforcement learning drives realistic virtual arm (Dura-Bernal et al 2015)

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Accession:183014
We developed a 3-layer sensorimotor cortical network of consisting of 704 spiking model-neurons, including excitatory, fast-spiking and low-threshold spiking interneurons. Neurons were interconnected with AMPA/NMDA, and GABAA synapses. We trained our model using spike-timing-dependent reinforcement learning to control a virtual musculoskeletal human arm, with realistic anatomical and biomechanical properties, to reach a target. Virtual arm position was used to simultaneously control a robot arm via a network interface.
References:
1 . Dura-Bernal S, Zhou X, Neymotin SA, Przekwas A, Francis JT, Lytton WW (2015) Cortical Spiking Network Interfaced with Virtual Musculoskeletal Arm and Robotic Arm. Front Neurorobot 9:13 [PubMed]
2 . Dura-Bernal S, Li K, Neymotin SA, Francis JT, Principe JC, Lytton WW (2016) Restoring behavior via inverse neurocontroller in a lesioned cortical spiking model driving a virtual arm. Front. Neurosci. Neuroprosthetics 10:28
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neocortex M1 pyramidal pyramidal tract L5B cell; Neocortex M1 pyramidal intratelencephalic L2-5 cell; Neocortex M1 interneuron basket PV cell; Neocortex fast spiking (FS) interneuron; Neostriatum fast spiking interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON; Python (web link to model);
Model Concept(s): Synaptic Plasticity; Learning; Reinforcement Learning; STDP; Reward-modulated STDP; Sensory processing; Motor control;
Implementer(s): Neymotin, Sam [samn at neurosim.downstate.edu]; Dura, Salvador [ salvadordura at gmail.com];
Search NeuronDB for information about:  Neocortex M1 pyramidal intratelencephalic L2-5 cell; Neocortex M1 pyramidal pyramidal tract L5B cell; Neocortex M1 interneuron basket PV cell; GabaA; AMPA; NMDA; Gaba; Glutamate;
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arm2dms_modeldb
mod
msarm
stimdata
README.html
analyse_funcs.py
analysis.py
armGraphs.py
arminterface_pipe.py
basestdp.hoc
bicolormap.py
boxes.hoc *
bpf.h *
col.hoc
colors.hoc *
declist.hoc *
decmat.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
filtutils.hoc *
grvec.hoc
hinton.hoc *
hocinterface.py
infot.hoc *
init.hoc
intfsw.hoc *
labels.hoc
load.hoc
load.py
local.hoc *
main.hoc
main_demo.hoc
main_neurostim.hoc
misc.h *
misc.py *
msarm.hoc
network.hoc
neuroplot.py *
neurostim.hoc
nload.hoc
nqs.hoc *
nqsnet.hoc *
nrnoc.hoc
params.hoc
perturb.hoc
python.hoc
pywrap.hoc *
run.hoc
runbatch_neurostim.py
runsim_neurostim
samutils.hoc *
saveoutput.hoc
saveoutput2.hoc
setup.hoc *
sim.hoc
sim.py
sim_demo.py
simctrl.hoc *
stats.hoc *
stim.hoc
syncode.hoc *
units.hoc *
vector.py
xgetargs.hoc *
                            
// $Id: default.hoc,v 1.5 2003/07/08 16:16:52 billl Exp $
/* This file contains various global defaults for hoc

** Users should not edit nrnoc.hoc or default.hoc.  Any local 
changes to these files should be made in local.hoc.
----------------------------------------------------------------*/

/*------------------------------------------------------------
Object defaults
------------------------------------------------------------*/

/*** Define a "nil" object ***/
objectvar nil

/*------------------------------------------------------------
String defaults
------------------------------------------------------------*/

/*** "Section" is used if errors are found in the initializiations ***/
strdef section

/*** Misc defines used by graphic routines ***/
temp_string_ = "t"
tempvar = 0

/*------------------------------------------------------------
Simulation defaults
------------------------------------------------------------*/

                        /* To be consistent w/the nmodl values */
FARADAY = 96520.        /* Hoc default = 96484.56 */
PI      = 3.14159       /* Hoc default = 3.1415927 */

                        /* 0=off, 1=on */
print_flag  = 0         /* Write to output file */
graph_flag  = 1         /* Plot output */
iv_flag     = 1         /* Using Interviews plotting */
batch_flag  = 0         /* Using batch_run() */
compress_flag = 0       /* Compress output file when saved */
stoprun     = 0         /* 0=running, 1=stopped */
iv_loaded   = 0         /* Load initial iv stuff on once */

init_seed   = 830529
run_seed    = 680612

t           = 0         /* msec */
dt          = .01       /* msec */
tstop       = 100       /* msec */
printStep   = 0.1       /* msec */
plotStep    = 0.1       /* msec */
flushStep   = 0.1       /* msec */
eventStep   = 50        /* Number of nstep's before a doEvent */

secondorder = 0

celsius     = 6.3       /* degC */

v_init      = -70       /* (mV) */
global_ra   = 200       /* (ohm-cm) specific axial resisitivity */

/*** Ion parameters ***/
ca_init     = 50e-6     /* mM */
na_init     = 10        /* mM */
k_init      = 54.4      /* mM */


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