In this paper we propose a new mechanism, diffusive homeostasis, in which neural excitability is modulated by nitric oxide, a gas which can flow freely across cell membranes. Our model simulates the activity-dependent synthesis and diffusion of nitric oxide in a recurrent network model of integrate-and-fire neurons. The concentration of nitric oxide is then used as homeostatic readout which modulates the firing threshold of each neuron.
Sweeney Y, Hellgren Kotaleski J, Hennig MH (2015) A Diffusive Homeostatic Signal Maintains Neural Heterogeneity and Responsiveness in Cortical Networks. PLoS Comput Biol 11:e1004389 [PubMed]