Allen Institute: Nr5a1-Cre VISp layer 2/3 473862496

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Accession:184327
This is an Allen Cell Types Database model of a Nr5a1-Cre neuron from layer 2/3 of the mouse primary visual cortex. The model was based on a traced morphology after filling the cell with biocytin and optimized using experimental electrophysiology data recorded from the same cell. The electrophysiology data was collected in a highly standardized way to facilitate comparison across all cells in the database. The model was optimized by a genetic algorithm that adjusted the densities of conductances placed at the soma to match experimentally-measured features of action potential firing. Data and models from the Allen Cell Types Database are made available to the community under the Allen Institute's Terms of Use and Citation Policy.
Reference:
1 . Allen Institute (2015) Documentation Allen Cell Types Database
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L2/6 pyramidal intratelencephalic cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Parameter Fitting; Calcium dynamics; Vision;
Implementer(s):
Search NeuronDB for information about:  Neocortex V1 L2/6 pyramidal intratelencephalic cell; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca;
Files displayed below are from the implementation
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473862496
modfiles
Ca_HVA.mod *
Ca_LVA.mod *
CaDynamics.mod *
Ih.mod *
Im.mod *
Im_v2.mod *
K_P.mod *
K_T.mod *
Kd.mod *
Kv2like.mod *
Kv3_1.mod *
Nap.mod *
NaTa.mod *
NaTs.mod *
NaV.mod *
SK.mod *
                            
:Reference : Modeled according to kinetics derived from Magistretti & Alonso 1999
:Comment: corrected rates using q10 = 2.3, target temperature 34, orginal 21

NEURON	{
	SUFFIX Nap
	USEION na READ ena WRITE ina
	RANGE gbar, g, ina
}

UNITS	{
	(S) = (siemens)
	(mV) = (millivolt)
	(mA) = (milliamp)
}

PARAMETER	{
	gbar = 0.00001 (S/cm2)
}

ASSIGNED	{
	v	(mV)
	ena	(mV)
	ina	(mA/cm2)
	g	(S/cm2)
	celsius (degC)
	mInf
	hInf
	hTau
	hAlpha
	hBeta
}

STATE	{
	h
}

BREAKPOINT	{
	SOLVE states METHOD cnexp
	rates()
	g = gbar*mInf*h
	ina = g*(v-ena)
}

DERIVATIVE states	{
	rates()
	h' = (hInf-h)/hTau
}

INITIAL{
	rates()
	h = hInf
}

PROCEDURE rates(){
  LOCAL qt
  qt = 2.3^((celsius-21)/10)

	UNITSOFF
		mInf = 1.0/(1+exp((v- -52.6)/-4.6)) : assuming instantaneous activation as modeled by Magistretti and Alonso

		hInf = 1.0/(1+exp((v- -48.8)/10))
		hAlpha = 2.88e-6 * vtrap(v + 17, 4.63)
		hBeta = 6.94e-6 * vtrap(-(v + 64.4), 2.63)

		hTau = (1/(hAlpha + hBeta))/qt
	UNITSON
}

FUNCTION vtrap(x, y) { : Traps for 0 in denominator of rate equations
	UNITSOFF
	if (fabs(x / y) < 1e-6) {
		vtrap = y * (1 - x / y / 2)
	} else {
		vtrap = x / (exp(x / y) - 1)
	}
	UNITSON
}

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