NMDA spikes in basal dendrites of L5 pyramidal neurons (Polsky et al. 2009)

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Accession:184725
"... In apical dendrites of neocortical pyramidal neurons, calcium spikes are known to contribute to burst generation, but a comparable understanding of basal dendritic mechanisms is lacking. Here we show that NMDA spikes in basal dendrites mediate both detection and generation of bursts through a postsynaptic mechanism. High-frequency inputs to basal dendrites markedly facilitated NMDA spike initiation compared with low-frequency activation or single inputs. ..."
Reference:
1 . Polsky A, Mel B, Schiller J (2009) Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. J Neurosci 29:11891-903 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell;
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; Glutamate;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Bursting; Action Potentials; Synaptic Integration;
Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell; AMPA; NMDA; Glutamate;
{load_file("nrngui.hoc")}
objectvar save_window_, rvp_
objectvar scene_vector_[5]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin PointProcessGroupManager
{
load_file("pointgrp.hoc")
}
{
ocbox_ = new PointProcessGroupManager(0)
}
{object_push(ocbox_)}
{
ms = new MechanismStandard("IClamp")
ms.set("del", 0, 0)
ms.set("dur", 200, 0)
ms.set("amp", 0, 0)
mnews("IClamp", ms)
select(0)
execute("celltemplate[0].soma ocbox_.move(0.5)")
ms = new MechanismStandard("glutamate")
ms.set("gnmdamax", 16, 0)
ms.set("gampamax", 0, 0)
ms.set("e", 0, 0)
ms.set("del", 100, 0)
ms.set("Tspike", 20, 0)
ms.set("Nspike", 2, 0)
ms.set("decayampa", 1, 0)
ms.set("decaynmda", 1, 0)
mnews("glutamate", ms)
select(1)
execute("celltemplate[0].dend[73] ocbox_.move(0.722222)")
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessGroupManager", 726, 15, 545.4, 620.1)
}
objref ocbox_
//End PointProcessGroupManager

{
xpanel("RunControl", 0)
v_init = -60
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 180
xvalue("t","t", 2 )
tstop = 180
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.1
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 10
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
screen_update_invl = 0.05
xvalue("Scrn update invl","screen_update_invl", 1,"", 0, 1 )
realtime = 1
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(2,135)
}
{
save_window_ = new Graph(0)
save_window_.size(0,180,-80,40)
scene_vector_[3] = save_window_
{save_window_.view(0, -80, 180, 120, 318, 465, 300.6, 200.8)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("cell.soma.v(0.5)", 2, 1, 0.8, 0.9, 2)
save_window_.addexpr("cell.dend[73].v(0.75)", 1, 1, 0.8, 0.9, 2)
}
{
save_window_ = new Graph(0)
save_window_.size(0,180,-60,-47)
scene_vector_[4] = save_window_
{save_window_.view(0, -60, 180, 13, 315, 115, 300.6, 200.8)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 1, 1, 0.8, 0.9, 2)
}
objectvar scene_vector_[1]
{doNotify()}

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