Salamander retinal ganglian cells: morphology influences firing (Sheasby, Fohlmeister 1999)

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Accession:18501
Nerve impulse entrainment and other excitation and passive phenomena are analyzed for a morphologically diverse and exhaustive data set (n=57) of realistic (3-dimensional computer traced) soma-dendritic tree structures of ganglion cells in the tiger salamander (Ambystoma tigrinum) retina.
Reference:
1 . Sheasby BW, Fohlmeister JF (1999) Impulse encoding across the dendritic morphologies of retinal ganglion cells. J Neurophysiol 81:1685-98 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Retina ganglion GLU cell;
Channel(s): I Na,t; I A; I K; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Activity Patterns; Dendritic Action Potentials; Bursting; Coincidence Detection; Simplified Models; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Axonal Action Potentials; Action Potentials; Calcium dynamics;
Implementer(s): Sheasby, Brent W ;
Search NeuronDB for information about:  Retina ganglion GLU cell; I Na,t; I A; I K; I K,Ca; I Calcium;
load_file("nrngui.hoc")

load_file("nrngui.hoc")


strdef tstr
objref vbox, hbox, hbox2

vbox = new VBox()
vbox.intercept(1)

    xpanel("Sheasby and Fohlmeister 1999 simulations")
    xlabel("Models of Cells from Sheasby and Fohlmeister 1999")
    xlabel("select below cells for current clamp simulations similar")
    xlabel("to those in the left column of figure 3.")
    xpanel()
    xpanel("selections of cells")
    
    hbox=new HBox()
    hbox.intercept(1)
        xlabel("Large")
        xradiobutton("ctt3219f", "restart(\"Large/CTT3219F/ctt3219f\")")
        xradiobutton("lws9287q", "restart(\"Large/LWS9287A/lws9287a\")")
        xradiobutton("lws9287q", "restart(\"Large/LWS9287Q/lws9287q\")")
        xradiobutton("lws9287r", "restart(\"Large/LWS9287R/lws9287r\")")
        
        xlabel("Medium Complex")
        xradiobutton("ctt1209a", "restart(\"MediumComplex/CTT1209A/ctt1209a\")")
        xradiobutton("ctt3219b", "restart(\"MediumComplex/CTT3219B/ctt3219b\")")
        xradiobutton("ctt3219g", "restart(\"MediumComplex/CTT3219G/ctt3219g\")")
        xradiobutton("ctt3219j", "restart(\"MediumComplex/CTT3219J/ctt3219j\")")
        xradiobutton("ctt3219n", "restart(\"MediumComplex/CTT3219N/ctt3219n\")")
        xradiobutton("ctty238f", "restart(\"MediumComplex/CTTY238F/ctty238f\")")
        xradiobutton("frsx097c", "restart(\"MediumComplex/FRSX097C/frsx097c\")")
        xradiobutton("frsx097f", "restart(\"MediumComplex/FRSX097F/frsx097f\")")
        xradiobutton("lws9287d", "restart(\"MediumComplex/LWS9287D/lws9287d\")")
        xradiobutton("lws9287f", "restart(\"MediumComplex/LWS9287F/lws9287f\")")
        xradiobutton("lws9287g", "restart(\"MediumComplex/LWS9287G/lws9287g\")")
        xradiobutton("lws9287h", "restart(\"MediumComplex/LWS9287H/lws9287h\")")
        xradiobutton("lws9287l", "restart(\"MediumComplex/LWS9287L/lws9287l\")")
        xradiobutton("lws9287m", "restart(\"MediumComplex/LWS9287M/lws9287m\")")
        xradiobutton("lws9287p", "restart(\"MediumComplex/LWS9287P/lws9287p\")")
        xradiobutton("lws9287s", "restart(\"MediumComplex/LWS9287S/lws9287s\")")
        xradiobutton("lws9287w", "restart(\"MediumComplex/LWS9287W/lws9287w\")")
        xradiobutton("lws9287y", "restart(\"MediumComplex/LWS9287Y/lws9287y\")")
        
        xpanel()
        xpanel("Medium Simple")
        xlabel("Medium Simple")
        xradiobutton("ctt3219c", "restart(\"MediumSimple/CTT3219C/ctt3219c\")")
        xradiobutton("ctt3219k", "restart(\"MediumSimple/CTT3219K/ctt3219k\")")
        xradiobutton("ctt3219m", "restart(\"MediumSimple/CTT3219M/ctt3219m\")")
        xradiobutton("ctt3219z", "restart(\"MediumSimple/CTT3219Z/ctt3219z\")")
        xradiobutton("ctty238f", "restart(\"MediumSimple/CTTY238F/ctty238f\")")
        xradiobutton("ctty118f", "restart(\"MediumSimple/CTTY118F/ctty118f\")")
        xradiobutton("lws9287b", "restart(\"MediumSimple/LWS9287B/lws9287b\")")
        xradiobutton("lws9287i", "restart(\"MediumSimple/LWS9287I/lws9287i\")")
        xradiobutton("lws9287j", "restart(\"MediumSimple/LWS9287J/lws9287j\")")
        xradiobutton("lws9287k", "restart(\"MediumSimple/LWS9287K/lws9287k\")")
        xradiobutton("lws9287n", "restart(\"MediumSimple/LWS9287N/lws9287n\")")
        xradiobutton("lws9287o", "restart(\"MediumSimple/LWS9287O/lws9287o\")")
        xradiobutton("lws9287u", "restart(\"MediumSimple/LWS9287U/lws9287u\")")
        xradiobutton("lws9287v", "restart(\"MediumSimple/LWS9287V/lws9287v\")")
        xradiobutton("lws9287x", "restart(\"MediumSimple/LWS9287X/lws9287x\")")
        xlabel("Small Complex")
        xradiobutton("cts7259g", "restart(\"SmallComplex/CTS7259G/cts7259g\")")
        xradiobutton("ctt3219h", "restart(\"SmallComplex/CTT3219H/ctt3219h\")")
        xradiobutton("ctty118a", "restart(\"SmallComplex/CTTY118A/ctty118a\")")
        xradiobutton("ctty118c", "restart(\"SmallComplex/CTTY118C/ctty118c\")")
        xradiobutton("ctty118e", "restart(\"SmallComplex/CTTY118E/ctty118e\")")
        xradiobutton("ctty238d", "restart(\"SmallComplex/CTTY238D/ctty238d\")")
        xradiobutton("ctty238g", "restart(\"SmallComplex/CTTY238G/ctty238g\")")
        xradiobutton("frsx097e", "restart(\"SmallComplex/FRSX097E/frsx097e\")")
        
        xpanel()
        xpanel("Small Simple")
        
        xlabel("Small Simple")
        xradiobutton("ctt1209b", "restart(\"SmallSimple/CTT1209B/ctt1209b\")")
        xradiobutton("ctt1209c", "restart(\"SmallSimple/CTT1209C/ctt1209c\")")
        xradiobutton("ctt1209d", "restart(\"SmallSimple/CTT1209D/ctt1209d\")")
        xradiobutton("ctt1209e", "restart(\"SmallSimple/CTT1209E/ctt1209e\")")
        xradiobutton("ctt1209f", "restart(\"SmallSimple/CTT1209F/ctt1209f\")")
        xradiobutton("ctt1209g", "restart(\"SmallSimple/CTT1209G/ctt1209g\")")
        xradiobutton("ctt1209h", "restart(\"SmallSimple/CTT1209H/ctt1209h\")")
        xradiobutton("ctt2249a", "restart(\"SmallSimple/CTT2249A/ctt2249a\")")
        xradiobutton("ctt2249c", "restart(\"SmallSimple/CTT2249C/ctt2249c\")")
        xradiobutton("ctt7259b", "restart(\"SmallSimple/CTT7259B/ctt7259b\")")
        xradiobutton("ctty118b", "restart(\"SmallSimple/CTTY118B/ctty118b\")")
        xradiobutton("ctty118d", "restart(\"SmallSimple/CTTY118D/ctty118d\")")
        xradiobutton("ctty238d", "restart(\"SmallSimple/CTTY238D/ctty238d\")")
        xradiobutton("ctty238a", "restart(\"SmallSimple/CTTY238A/ctty238a\")",1)  // mark button on
        
        xpanel()
    hbox.intercept(0)
    hbox.map()



    hbox2 = new HBox()
    hbox2.intercept(1)
    xpanel("figure6")
	xlabel("Select a Medium Complex cell then press")
	xpanel()
	xpanel("thebutton")
        xbutton("Figure 6","fig6()")
	xpanel()
	xpanel("more info")
	xlabel("(narrow diam can be changed)")
	xpanel()
    hbox2.intercept(0)
    hbox2.map()
	

    xpanel("figure10BC")
    xbutton("Figure 10 B,C","fig10bc()")
    xpanel()

vbox.intercept(0)
vbox.map()

pwmcnt = PWManager[0].count // the initial guis should not be dismissed

proc delete_graphs() {

	objref graphItem, save_window_
	for i=0, n_graph_lists-1 {
		graphList[i].remove_all()
	}
	flush_list.remove_all()
	fast_flush_list.remove_all()
	doNotify()
	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
		PWManager[0].close(i)
		doNotify()
	}
}

proc delete_cells() {
	forall delete_section()	// this removes the previous cell if there is one
}

proc restart() {local i

	delete_graphs()	
	delete_cells()

	stoprun = 0
	dt = .025

	tstop = 150
	print "loading: ",$s1    
	sprint(tstr, "%s.asc", $s1)
	load_file(1, tstr)
	sprint(tstr, "%s.hoc", $s1)
	load_file(1, tstr)
	load_file(1,"first.ses")
	init()
	run()
}


						// the last cell in the list...
proc fig6() {
	delete_graphs()
	load_file("anti.ses")
	move_iclamp2axon()

	xpanel("fig6")
	xlabel("selecting MediumComplex cell ctty238f shows interesting")
	xlabel("behavior around the narrow region diameter = 0.45")
	xvalue("narrow region diam","narrowr.diam")
	xpanel()

	dt=.1
	tstop=30

	init()
	run()
}

proc fig10bc() {
	delete_graphs()
	delete_cells()
	load_file("MediumComplex/CTT1209A/ctt1209a.asc")
	load_file("ctt1209a_denstim.hoc")
	load_file("soma_dend_v.ses")
	init()
	run()
}



restart("SmallSimple/CTTY238A/ctty238a")	// this automatically starts the simulation with


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