Spine fusion and branching effects synaptic response (Rusakov et al 1996, 1997)

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Accession:18502
This compartmental model of a hippocampal granule cell has spinous synapses placed on the second-order dendrites. Changes in shape and connectivity of the spines usually does not effect the synaptic response of the cell unless active conductances are incorporated into the spine membrane (e.g. voltage-dependent Ca2+ channels). With active conductances, spines can generate spike-like events. We showed that changes like fusion and branching, or in fact any increase in the equivalent spine neck resistance, could trigger a dramatic increase in the spine's influence on the dendritic shaft potential.
References:
1 . Rusakov DA, Richter-Levin G, Stewart MG, Bliss TV (1997) Reduction in spine density associated with long-term potentiation in the dentate gyrus suggests a spine fusion-and-branching model of potentiation. Hippocampus 7:489-500 [PubMed]
2 . Rusakov DA, Stewart MG, Korogod SM (1996) Branching of active dendritic spines as a mechanism for controlling synaptic efficacy. Neuroscience 75:315-23 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule cell;
Channel(s): I Na,t; I K; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Plasticity; Long-term Synaptic Plasticity;
Implementer(s): Rusakov, DA [D.Rusakov at ion.ucl.ac.uk];
Search NeuronDB for information about:  Dentate gyrus granule cell; AMPA; NMDA; I Na,t; I K; I K,Ca; I Sodium; I Calcium; I Potassium;
load_file("nrngui.hoc")

strdef tstr

xpanel("Figure 2 Rusakov et. al. 1997")
xlabel("20 percent of spines split with:")
xbutton("branch near shaft", "{print \"split near shaft\" restart(\"ltp_two\")}")
xbutton("regular sized necks", "{print \"regular sized necks\" restart(\"ltp_spl\")}")
xlabel("Control: With interval of constant soma injection and")
xlabel("random topography of dendrite spines with NMDA currents proportional to:")
xbutton("0.25 nS AMPA", "{print \"AMPA cur=0.25nS\" restart(\"ltp_ran\")}")
xbutton("0.35 nS AMPA", "{print \"AMPA cur=0.35nS\" restart(\"ltp_ttt\")}")
xpanel(456,462)

pwmcnt = PWManager[0].count // the initial gui should not be dismissed

proc restart() {local i
//	objref graphItem, save_window_
//	for i=0, n_graph_lists-1 {
//		graphList[i].remove_all()
//	}
//	flush_list.remove_all()
//	fast_flush_list.remove_all()
//	doNotify()
//	for (i= PWManager[0].count-1; i >= pwmcnt; i -= 1) {
//		PWManager[0].close(i)
//		doNotify()
//	}
	
	stoprun = 0
	dt = .025
	steps_per_ms = 40
	tstop = 50
	sprint(tstr, "%s.hoc", $s1)
	load_file(1, tstr)
	load_file("shape_spine_V.ses")
	init()
	run()
}

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