Effects of neural morphology on global and focal NMDA-spikes (Poleg-Polsky 2015)

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Accession:185123
This entry contains the NEURON files required to recreate figures 4-8 of the paper "Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-spikes" by Alon Poleg-Polsky
Reference:
1 . Poleg-Polsky A (2015) Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-Spikes. PLoS One 10:e0140254 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse; Dendrite;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; Neocortex layer 4 neuron;
Channel(s): I N; I K; I K,leak;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Ion Channel Kinetics; Active Dendrites; Detailed Neuronal Models; Synaptic Integration; Synaptic-input statistic; Dendritic Bistability;
Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell; AMPA; NMDA; I N; I K; I K,leak;
{load_file("nrngui.hoc")}
objectvar save_window_, rvp_
objectvar scene_vector_[6]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin PointProcessGroupManager
{
load_file("pointgrp.hoc")
}
{
ocbox_ = new PointProcessGroupManager(0)
}
{object_push(ocbox_)}
{
ms = new MechanismStandard("IClamp")
ms.set("del", 0, 0)
ms.set("dur", 0, 0)
ms.set("amp", 0, 0)
mnews("IClamp", ms)
select(0)
execute("celltemplate[0].soma ocbox_.move(0.5)")
ms = new MechanismStandard("OClamp")
ms.set("rs", 25, 0)
ms.set("on", 0, 0)
ms.set("off", 600, 0)
ms.set("vc", 30, 0)
ms.set("switched_on", 0, 0)
mnews("OClamp", ms)
select(1)
execute("celltemplate[0].soma ocbox_.move(0.5)")
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessGroupManager", 986, 644, 545.4, 316.8)
}
objref ocbox_
//End PointProcessGroupManager


{
save_window_ = new Graph(0)
save_window_.size(-10,620,0.0162833,0.834117)
scene_vector_[5] = save_window_
{save_window_.view(-10, 0.0162833, 630, 0.817833, 1462, 78, 300.6, 200.8)}
graphList[1].append(save_window_)
save_window_.save_name("graphList[1].")
save_window_.addexpr("OClamp[0].i", 1, 1, 0.8, 0.9, 2)
save_window_.addexpr("IClamp[0].i", 1, 1, 0.8, 0.9, 2)

}
objectvar scene_vector_[1]
{doNotify()}

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