VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)

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Accession:185330
" ... Here we present a biophysical model of a DA VTA neuron based on 3D morphological reconstruction and electrophysiological data, showing how opiates withdrawal-driven morphological and electrophysiological changes could affect the firing rate and discharge pattern...."
Reference:
1 . Enrico P, Migliore M, Spiga S, Mulas G, Caboni F, Diana M (2016) Morphofunctional alterations in ventral tegmental area dopamine neurons in acute and prolonged opiates withdrawal. A computational perspective. Neuroscience 322:195-207 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Addiction;
Implementer(s): Enrico, Paolo [enrico at uniss.it];
/
EnricoEtAl2016
README.html
cabal.mod *
cachan.mod
capump.mod *
dop.mod *
hh3.mod
IhDA.mod
kca.mod
nabalan.mod
netstimd.mod
newleak.mod
nmdanet.mod *
pump.mod *
CellDef.hoc
ctrlfiring_cnt.txt
DA_release.ses
DA_release_final.hoc
DA_release_withdrawal_final.hoc
DA_release_withdrawal_final_noGLU.hoc
firing_cnt.txt
fixnseg.hoc *
mosinit.hoc
screenshot.png
screenshot2.png
                            
TITLE Calcium ion accumulation without diffusion and buffering
 
                 
NEURON {
	SUFFIX cabalan
	USEION ca READ cai, ica WRITE cai
	RANGE  cainit, fCa , icapump,icapumpmax,km
}

UNITS {
	(molar) = (1/liter)
	(mM) =  (millimolar)
	(um) =  (micron)
	(mA) =  (milliamp)
	FARADAY = (faraday) (coulomb) 
	PI = (pi) (1)
}

PARAMETER {
         fCa = 0.05  (1)
         cainit = 0.00002 (mM)
        dt    (ms)
        celsius = 35  (degC)
        icapumpmax  = 0.00191  (mA/cm2)
        km = 0.000500         (mM)
         }

ASSIGNED {
	diam  (um)
	ica   (mA/cm2)
          icapump (mA/cm2)
}

STATE {
	cai (mM) <1e-10>
}

BREAKPOINT {
	SOLVE state METHOD sparse
}

INITIAL{
        cai=cainit
}

KINETIC state {
        icapump = icapumpmax*(1/(1 + km/cai))
	COMPARTMENT PI*diam*diam/4 {cai}
	 ~ cai << (-fCa*(ica +icapump)*PI*diam*(1e4)/(2*FARADAY))
}

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