VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)

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Accession:185330
" ... Here we present a biophysical model of a DA VTA neuron based on 3D morphological reconstruction and electrophysiological data, showing how opiates withdrawal-driven morphological and electrophysiological changes could affect the firing rate and discharge pattern...."
Reference:
1 . Enrico P, Migliore M, Spiga S, Mulas G, Caboni F, Diana M (2016) Morphofunctional alterations in ventral tegmental area dopamine neurons in acute and prolonged opiates withdrawal. A computational perspective. Neuroscience 322:195-207 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Addiction;
Implementer(s): Enrico, Paolo [enrico at uniss.it];
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EnricoEtAl2016
README.html
cabal.mod *
cachan.mod
capump.mod *
dop.mod *
hh3.mod
IhDA.mod
kca.mod
nabalan.mod
netstimd.mod
newleak.mod
nmdanet.mod *
pump.mod *
CellDef.hoc
ctrlfiring_cnt.txt
DA_release.ses
DA_release_final.hoc
DA_release_withdrawal_final.hoc
DA_release_withdrawal_final_noGLU.hoc
firing_cnt.txt
fixnseg.hoc *
mosinit.hoc
screenshot.png
screenshot2.png
                            
TITLE Calcium dependent potassium channel (small conductance SK)
 

UNITS {
        (molar) = (1/liter)
        (pA) =  (picoamp)
	(mV) =	(millivolt)
        (S)  =  (siemens)
	(mA) =	(milliamp)
	(mM) =	(millimolar)
}


INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}

NEURON {
	SUFFIX kca
	USEION ca READ cai
	USEION k WRITE ik
	RANGE  gkbar,km,oinf,n, ik
 
}


PARAMETER {
        dt  (ms)
        cai (mM)
        celsius = 35   (degC)
        gkbar = 800e-6 (S/cm2)
        ek = -90      (mV)
        km = 0.00019   (mM)
        n  = 4.0       (1)
        
        
}

ASSIGNED { 
           ik		(mA/cm2)
           oinf           
}


BREAKPOINT {
        oinf = 1/(1 + (km/cai)^4)
	ik = oinf*gkbar*(v - ek)
}


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