VTA neurons: Morphofunctional alterations in acute opiates withdrawal (Enrico et al. 2016)

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Accession:185330
" ... Here we present a biophysical model of a DA VTA neuron based on 3D morphological reconstruction and electrophysiological data, showing how opiates withdrawal-driven morphological and electrophysiological changes could affect the firing rate and discharge pattern...."
Reference:
1 . Enrico P, Migliore M, Spiga S, Mulas G, Caboni F, Diana M (2016) Morphofunctional alterations in ventral tegmental area dopamine neurons in acute and prolonged opiates withdrawal. A computational perspective. Neuroscience 322:195-207 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Ventral tegmental area dopamine neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Addiction;
Implementer(s): Enrico, Paolo [enrico at uniss.it];
/
EnricoEtAl2016
README.html
cabal.mod *
cachan.mod
capump.mod *
dop.mod *
hh3.mod
IhDA.mod
kca.mod
nabalan.mod
netstimd.mod
newleak.mod
nmdanet.mod *
pump.mod *
CellDef.hoc
ctrlfiring_cnt.txt
DA_release.ses
DA_release_final.hoc
DA_release_withdrawal_final.hoc
DA_release_withdrawal_final_noGLU.hoc
firing_cnt.txt
fixnseg.hoc *
mosinit.hoc
screenshot.png
screenshot2.png
                            
TITLE Leak current including GABA_A receptor current
 

UNITS {
        (pA) = (picoamp)
        (molar) = (1/liter)
	(mV) =	(millivolt)
        (S)  =  (siemens)
	(mA) =	(milliamp)
	(mM) =	(millimolar)
         F = (faraday) (coulomb)
         R = (mole k)  (mV-coulomb/degC)
}


INDEPENDENT {v FROM -100 TO 50 WITH 50 (mV)}

NEURON {
	SUFFIX leak
	USEION ca WRITE ica
	USEION na READ nai,ena  WRITE ina
	USEION k  WRITE ik
	USEION cl WRITE icl VALENCE -1
	RANGE  gcabar,ileak,ina,ica,ik,gnabar,gkbar,nai,ggabaa
 
}

PARAMETER {
        dt      (ms)
        ena     (mV)
        nai     (mM)
        celsius = 35      (degC)
        gkbar   = 5.5e-6 (S/cm2)
        gnabar  = 2.375e-6  (mho/cm2)
        gcabar  = 0.0136e-6  (mho/cm2)
        ggabaa  = 1.0e-6  (mho/cm2)
        eca =   120 (mV)
        ecl =  -70  (mV)
        ek  =  -90.0 (mV)
        nao =   145 (mM)
        
}

ASSIGNED { 
           ica	  (mA/cm2)
           ina	  (mA/cm2)
           ik	  (mA/cm2)
           icl	  (mA/cm2)
           ileak  (mA/cm2)
}


BREAKPOINT {
        ena = R*(celsius+273.15)/F*log(nao/nai)
	ica = gcabar*(v-eca)
	ina = gnabar*(v-ena)
	icl = ggabaa*(v-ecl)
	ik = gkbar*(v-ek)
        ileak= ica + ina + ik + icl 
}

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