Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)

 Download zip file 
Help downloading and running models
Accession:185858
"Neuronal persistent activity has been primarily assessed in terms of electrical mechanisms, without attention to the complex array of molecular events that also control cell excitability. We developed a multiscale neocortical model proceeding from the molecular to the network level to assess the contributions of calcium regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in providing additional and complementary support of continuing activation in the network. ..."
Reference:
1 . Neymotin SA, McDougal RA, Bulanova AS, Zeki M, Lakatos P, Terman D, Hines ML, Lytton WW (2016) Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex Neuroscience 316:344-366 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Molecular Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell; Neocortex V1 interneuron basket PV cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron; Neocortex layer 6a interneuron;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium; I_AHP; I_KD; Ca pump;
Gap Junctions:
Receptor(s): mGluR1; GabaA; GabaB; AMPA; NMDA; mGluR; Glutamate; Gaba; IP3;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Oscillations; Spatio-temporal Activity Patterns; Signaling pathways; Working memory; Attractor Neural Network; Calcium dynamics; Laminar Connectivity; G-protein coupled; Rebound firing; Brain Rhythms; Dendritic Bistability; Reaction-diffusion; Beta oscillations; Persistent activity; Multiscale;
Implementer(s): Neymotin, Sam [samn at neurosim.downstate.edu]; McDougal, Robert [robert.mcdougal at yale.edu];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell; Neocortex V1 interneuron basket PV cell; mGluR1; GabaA; GabaB; AMPA; NMDA; mGluR; Glutamate; Gaba; IP3; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium; I_AHP; I_KD; Ca pump; Gaba; Glutamate;
/
CaHDemo
readme.html
cagk.mod
cal.mod *
calts.mod *
can.mod *
cat.mod *
gabab.mod
IC.mod *
icalts.mod *
Ih.mod
ihlts.mod *
IKM.mod *
kap.mod
kcalts.mod *
kdmc.mod
kdr.mod
kdrbwb.mod
km.mod *
mglur.mod *
misc.mod
MyExp2SynBB.mod *
MyExp2SynNMDABB.mod
nafbwb.mod
nax.mod
vecst.mod *
aux_fun.inc *
conf.py
declist.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
geom.py
ghk.inc *
grvec.hoc
init.hoc
labels.hoc
labels.py *
local.hoc *
misc.h
mpisim.py
netcfg.cfg
nqs.hoc
nqs.py
nrnoc.hoc *
onepyr.cfg
onepyr.py
pyinit.py *
python.hoc *
pywrap.hoc *
screenshot.png
screenshot1.png
simctrl.hoc *
simdat.py
syncode.hoc *
xgetargs.hoc *
                            
TITLE K-DR channel
: from Klee Ficker and Heinemann
: modified to account for Dax et al.
: M.Migliore 1997
: thread-safe 2010-05-31 Ben Suter
: 2010-11-07 Ben Suter, removing "kdr" from parameter names, reformatting, setting sh = 0 (was 24 mV)
:
: :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
: Copyright 2011, Benjamin Suter (for changes only)
: :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::


UNITS {
    (mA) = (milliamp)
    (mV) = (millivolt)
}

PARAMETER {
    v                   (mV)
    celsius             (degC)
    ek                  (mV)     : must be explicitely def. in hoc

    gbar    = 0.003     (mho/cm2)
    vhalfn  = 13        (mV)
    a0n     = 0.02      (/ms)
    zetan   = -3        (1)
    gmn     = 0.7       (1)
    nmax    = 2         (1)
    q10     = 1
    sh      = 0
}

NEURON {
    THREADSAFE
    SUFFIX kdr
    USEION k READ ek WRITE ik
    RANGE g, gbar, sh, ninf,taun
}

STATE {
    n
}

ASSIGNED {
    ik      (mA/cm2)
    ninf
    g
    taun
}

BREAKPOINT {
    SOLVE states METHOD cnexp
    g = gbar*n
    ik = g*(v-ek)
}

INITIAL {
    rates(v)
    n=ninf
}

FUNCTION alpn(v(mV)) {
    alpn = exp(1.e-3*zetan*(v-vhalfn-sh)*9.648e4/(8.315*(273.16+celsius)))
}

FUNCTION betn(v(mV)) {
    betn = exp(1.e-3*zetan*gmn*(v-vhalfn-sh)*9.648e4/(8.315*(273.16+celsius)))
}

DERIVATIVE states {     : exact when v held constant; integrates over dt step
    rates(v)
    n' = (ninf - n)/taun
}

PROCEDURE rates(v (mV)) { :callable from hoc
    LOCAL a,qt
    qt = q10^((celsius-24)/10)

    a = alpn(v)
    ninf = 1/(1+a)
    taun = betn(v)/(qt*a0n*(1+a))
    if (taun<nmax) {
        taun = nmax/qt
    }
}

Loading data, please wait...