Ca+/HCN channel-dependent persistent activity in multiscale model of neocortex (Neymotin et al 2016)

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Accession:185858
"Neuronal persistent activity has been primarily assessed in terms of electrical mechanisms, without attention to the complex array of molecular events that also control cell excitability. We developed a multiscale neocortical model proceeding from the molecular to the network level to assess the contributions of calcium regulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in providing additional and complementary support of continuing activation in the network. ..."
Reference:
1 . Neymotin SA, McDougal RA, Bulanova AS, Zeki M, Lakatos P, Terman D, Hines ML, Lytton WW (2016) Calcium regulation of HCN channels supports persistent activity in a multiscale model of neocortex Neuroscience 316:344-366 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse; Channel/Receptor; Molecular Network;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell; Neocortex V1 interneuron basket PV cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex layer 2-3 interneuron; Neocortex layer 5 interneuron; Neocortex layer 6a interneuron;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium; I_AHP; I_KD; Ca pump;
Gap Junctions:
Receptor(s): mGluR1; GabaA; GabaB; AMPA; NMDA; mGluR; Glutamate; Gaba; IP3;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics; Oscillations; Spatio-temporal Activity Patterns; Signaling pathways; Working memory; Attractor Neural Network; Calcium dynamics; Laminar Connectivity; G-protein coupled; Rebound firing; Brain Rhythms; Dendritic Bistability; Reaction-diffusion; Beta oscillations; Persistent activity; Multiscale;
Implementer(s): Neymotin, Sam [samn at neurosim.downstate.edu]; McDougal, Robert [robert.mcdougal at yale.edu];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell; Neocortex V1 L2/6 pyramidal intratelencephalic cell; Neocortex V1 interneuron basket PV cell; mGluR1; GabaA; GabaB; AMPA; NMDA; mGluR; Glutamate; Gaba; IP3; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I CAN; I Calcium; I_AHP; I_KD; Ca pump; Gaba; Glutamate;
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CaHDemo
readme.html
cagk.mod
cal.mod *
calts.mod *
can.mod *
cat.mod *
gabab.mod
IC.mod *
icalts.mod *
Ih.mod
ihlts.mod *
IKM.mod *
kap.mod
kcalts.mod *
kdmc.mod
kdr.mod
kdrbwb.mod
km.mod *
mglur.mod *
misc.mod
MyExp2SynBB.mod *
MyExp2SynNMDABB.mod
nafbwb.mod
nax.mod
vecst.mod *
aux_fun.inc *
conf.py
declist.hoc *
decnqs.hoc *
decvec.hoc *
default.hoc *
drline.hoc *
geom.py
ghk.inc *
grvec.hoc
init.hoc
labels.hoc
labels.py *
local.hoc *
misc.h
mpisim.py
netcfg.cfg
nqs.hoc
nqs.py
nrnoc.hoc *
onepyr.cfg
onepyr.py
pyinit.py *
python.hoc *
pywrap.hoc *
screenshot.png
screenshot1.png
simctrl.hoc *
simdat.py
syncode.hoc *
xgetargs.hoc *
                            
[seed]
iseed = 1234
wseed = 4321
pseed = 4321
[netsyn]
NMAMREE = 0.1
NMAMREI = 0.1
mGLURR = 0.0
GB2R = 7.5
rdmsec = 1
nmfracca = 0.13
[chan]
ihginc = 2.0
ihscale = 1.0
ilscale = 1.0
ikmscale = 1.0
iark2fctr = 1.0
iark4 = 0.008
erevh = -30.0
h_lambda = 325.0
h_gbar = 0.0025
cagk_gbar = 0.0001
ikc_gkbar = 0.003
expk = 1
cabar = 0.005
[cada]
taur = 5
[run]
indir = data
outdir = data
tstop = 14000
dt = 0.1
saveout = 1
simstr = 15dec31_1
packspikes = 0
dorun = 1
doquit = 1
dodraw = 0
verbose = 0
saveExtra = 0
cvodeactive = 0
recdt = 10
recvdt = 1
binsz = 5
[rxd]
CB_frate = 5.5
CB_brate = 0.0026
CB_init = 0.2
gip3 = 120400.0
gserca = 4.0
gleak = 3.0
cacytinit = 100e-6
caerinit = 1.25
caexinit = 0.0
spaceum = 0.0
nsubseg = 0
subsegum = 0.0
[net]
scale = 1.0
wirety = swire
IIGain = 0.75e-4
IEGain = 0.1
EIGainFS = 0.002
EIGainLTS = 0.002
EEGain = 0.00025
[mem]
baset = 1e3
nqm = None
useWM = 1
startt = 10e3
nMem = 1
nMemInhib = 0
intert = 4e3
durt = 100
rate = 500
weight = 0.0036
frac = 0.5,0.5,0.5,0.5
mGLURRWM = 1000.0
NMAMRWM = 1.0
AMRWM = 1.0
GARWM = 10.0
same = 0
lastmGLURON = 0
lastdurt = 1e3
apicIDX = 0
pops = E2,E5R,E5B,E6
[stim]
EXGain = 1.0
noise = 1
sgrhzNMI = 300.0
sgrhzNME = 300.0
sgrhzEE = 800.0
sgrhzEI = 800.0
sgrhzIE = 150.0
sgrhzII = 150.0
sgrhzMGLURE = 0.0
sgrhzGB2 = 0.0

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