CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)

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Accession:186768
This computational study investigates how a CA3 neuronal network consisting of pyramidal cells, basket cells and OLM interneurons becomes epileptic when dendritic inhibition to pyramidal cells is impaired due to the dysfunction of OLM interneurons. After standardizing the baseline activity (theta-modulated gamma oscillations), systematic changes are made in the connectivities between the neurons, as a result of step-wise impairment of dendritic inhibition.
Reference:
1 . Sanjay M, Neymotin SA, Krothapalli SB (2015) Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3. Hippocampus 25:1336-50 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Activity Patterns; Oscillations; Pathophysiology; Epilepsy; Brain Rhythms;
Implementer(s): Neymotin, Sam [samn at neurosim.downstate.edu]; Sanjay, M [msanjaycmc at gmail.com];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; GabaA; AMPA; NMDA;
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SanjayEtAl2015
readme.html
CA1ih.mod *
CA1ika.mod *
CA1ikdr.mod *
CA1ina.mod *
caolmw.mod *
capr.mod *
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iholmkop.mod *
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MyExp2Syn.mod *
MyExp2SynAlpha.mod *
MyExp2SynBB.mod *
MyExp2SynNMDA.mod *
MyExp2SynNMDABB.mod *
nafbwb.mod *
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Epileptic Activity.png
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mosinit.py
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networkmsj.py
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params.py
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xtmp
                            
: $Id: nafbwb.mod,v 1.4 2010/12/13 21:35:08 samn Exp $ 
COMMENT

//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
//
// NOTICE OF COPYRIGHT AND OWNERSHIP OF SOFTWARE
//
// Copyright 2007, The University Of Pennsylvania
// 	School of Engineering & Applied Science.
//   All rights reserved.
//   For research use only; commercial use prohibited.
//   Distribution without permission of Maciej T. Lazarewicz not permitted.
//   mlazarew@seas.upenn.edu
//
//%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%

ENDCOMMENT

UNITS {
  (mA) = (milliamp)
  (mV) = (millivolt)
  (mS) = (millisiemens)
}

NEURON {
  SUFFIX Nafbwb
  USEION na WRITE ina
  RANGE phih
  RANGE gna, ena, taoh : testing
}
	
PARAMETER {
  gna  = 35 (mS/cm2)
  ena  = 55 (mV)
  phih = 5
}
    
ASSIGNED {
  v       (mV)
  ina     (mA/cm2)
  minf    (1)
  hinf    (1)
  taoh    (ms)
  celsius (degC)
}

STATE { h }

PROCEDURE iassign () { ina = (1e-3) * gna * minf^3 * h * (v-ena) }

INITIAL {
  rates(v)
  h = hinf
  iassign()
}

BREAKPOINT {
  SOLVE states METHOD cnexp	
  iassign()
}

DERIVATIVE states { 
  rates(v)
  h' = (hinf-h)/taoh
}

PROCEDURE rates(v(mV)) { LOCAL am, bm, ah, bh, q10
    
  q10  = phih:^((celsius-27.0(degC))/10.0(degC))	
    
  am   = fun3(v,  -35, -0.1,    -10)
  bm   = fun1(v,  -60,  4,      -18) 
  minf = am/(am+bm)
 
  ah   = fun1(v,  -58,    0.07,  -20)
  bh   = fun2(v,  -28,    1,     -10)
  hinf = ah/(ah+bh)
  taoh = 1./((ah+bh)*q10)
}

INCLUDE "aux_fun.inc"

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