CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)

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Accession:186768
This computational study investigates how a CA3 neuronal network consisting of pyramidal cells, basket cells and OLM interneurons becomes epileptic when dendritic inhibition to pyramidal cells is impaired due to the dysfunction of OLM interneurons. After standardizing the baseline activity (theta-modulated gamma oscillations), systematic changes are made in the connectivities between the neurons, as a result of step-wise impairment of dendritic inhibition.
Reference:
1 . Sanjay M, Neymotin SA, Krothapalli SB (2015) Impaired dendritic inhibition leads to epileptic activity in a computer model of CA3. Hippocampus 25:1336-50 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Extracellular;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; Hippocampus CA3 stratum oriens lacunosum-moleculare interneuron;
Channel(s):
Gap Junctions:
Receptor(s): GabaA; AMPA; NMDA;
Gene(s): HCN1; HCN2;
Transmitter(s):
Simulation Environment: NEURON; Python;
Model Concept(s): Activity Patterns; Oscillations; Pathophysiology; Epilepsy; Brain Rhythms;
Implementer(s): Neymotin, Sam [samn at neurosim.downstate.edu]; Sanjay, M [msanjaycmc at gmail.com];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; Hippocampus CA3 basket cell; GabaA; AMPA; NMDA;
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SanjayEtAl2015
readme.html
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Epileptic Activity.png
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params.py
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xtmp
                            
// $Id: simctrl.hoc,v 1.14 2000/11/27 21:59:33 billl Exp $
// Graphic routines for neuremacs simulation control

proc sim_panel () {
  xpanel(simname)
        xvarlabel(output_file)
	xbutton("Init", "stdinit()")
	xbutton("Init & Run", "run()")
	xbutton("Stop", "stoprun=1")
	xbutton("Continue till Tstop", "continueRun(tstop)")
	xvalue("Continue till", "runStopAt", 1, "{continueRun(runStopAt) stoprun=1}", 1, 1)
	xvalue("Continue for", "runStopIn", 1, "{continueRun(t + runStopIn) stoprun=1}", 1,1)
	xbutton("Single Step", "steprun()")
	xvalue("Tstop", "tstop", 1, "tstop_changed()", 0, 1)
	graphmenu()
	sim_menu_bar()
	misc_menu_bar()
  xpanel()
}

proc misc_menu_bar() {
  xmenu("Miscellaneous")
    xbutton("Label Graphs", "labelgrs()")
    xbutton("Label With String", "labelwith()")
    xbutton("Label Panel", "labelpanel()")
	xbutton("Parameterized Function", "load_template(\"FunctionFitter\") makefitter()")
  xmenu()
}

proc sim_menu_bar() {
  xmenu("Simulation Control")
    xbutton("File Vers", "elisp(\"sim-current-files\")")
    xbutton("File Status...", "elisp(\"sim-rcs-status\")")
    xbutton("Sim Status", "elisp(\"sim-portrait\")")
    xbutton("Load Current Files", "elisp(\"sim-load-sim\")")
    xbutton("Load Templates", "elisp(\"sim-load-templates\")") 
    xbutton("Load File...", "elisp(\"sim-load-file\")") 
    xbutton("Save Sim...", "elisp(\"sim-save-sim\")")
    xbutton("Set File Vers...", "elisp(\"sim-set-file-ver\")")
    xbutton("Read Current Vers From Index", "elisp(\"sim-read-index-file\")")
    xbutton("Read Last Saved Vers", "elisp(\"sim-read-recent-versions\")")
    xbutton("Output to sim buffer", "elisp(\"sim-direct-output\")")
  xmenu()
}

proc labelpanel() {
  xpanel(simname,1)
	xvarlabel(output_file)
  xpanel()
}

proc labels () {
  labelwith($s1)
  labelgrs()
}

proc labelgrs () { local i, j, cnt
  for j=0,n_graph_lists-1 {
    cnt = graphList[j].count() - 1
    for i=0,cnt labelgr(graphList[j].object(i))
  }
}

proc labelwith () { local i, j, cnt
  temp_string_ = user_string_  // save the old one
  if (numarg() == 1) { /* interactive mode */  
    user_string_ = $s1
  } else {
    string_dialog("write what?", user_string_)
  }
  for j=0,n_graph_lists-1 {
    cnt = graphList[j].count() - 1
    for i=0,cnt {
      graphList[j].object(i).color(0)
      graphList[j].object(i).label(0.5,0.9,temp_string_)
      graphList[j].object(i).color(1)
      graphList[j].object(i).label(0.5,0.9,user_string_)
    }
  }
}

proc labelgr () { local i
  $o1.color(0)  // white overwrite
  for (i=0;i<10;i=i+1) { // erase every possible runnum for this date
    sprint(temp_string_,"%s %d%d",datestr,i,i)
    $o1.label(0.1,0.7,temp_string_) }
  $o1.color(1) // back to basic black
  sprint(temp_string_,"%s %02d",datestr,runnum)
  $o1.label(0.1,0.7,temp_string_)
}


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