Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)

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Accession:187605
The endocannabinoid (eCB) system is considered involved in synaptic depression. Recent reports have also linked eCBs to synaptic potentiation. However it is not known how eCB signaling may support such bidirectionality. To question the mechanisms of this phenomena in spike-timing dependent plasticity (STDP) at corticostriatal synapses, we combined electrophysiology experiments with biophysical modeling. We demonstrate that STDP is controlled by eCB levels and dynamics: prolonged and moderate levels of eCB lead to eCB-mediated long-term depression (eCB-tLTD) while short and large eCB transients produce eCB-mediated long-term potentiation (eCB-tLTP). Therefore, just like neurotransmitters glutamate or GABA, eCB form a bidirectional system.
Reference:
1 . Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, Berry H (2016) Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. Elife 5:e13185 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum spiny neuron;
Channel(s): I L high threshold; I Calcium; I_SERCA; I Cl, leak; Ca pump;
Gap Junctions:
Receptor(s): AMPA; NMDA; mGluR; Glutamate; IP3;
Gene(s):
Transmitter(s):
Simulation Environment: FORTRAN; Python;
Model Concept(s): Ion Channel Kinetics; Coincidence Detection; Parameter Fitting; Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; STDP; Calcium dynamics; Parameter sensitivity; G-protein coupled; Neuromodulation;
Implementer(s):
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; AMPA; NMDA; mGluR; Glutamate; IP3; I L high threshold; I Calcium; I_SERCA; I Cl, leak; Ca pump;
#!/bin/bash

# (c) 2016 - Ilya Prokin - isprokin@gmail.com - https://sites.google.com/site/ilyaprokin
# INRIA Rhone-Alpes
# STDP model : script to compile model with gfortran and f2py

LODEFOLDER='./odepack'
F2PY='python2 f2py2.py'
NAME="solve_py"

#compile odepack
cd $LODEFOLDER
for FILE in `ls -1 *.f`; do
    gfortran -c -Ofast -fPIC $FILE
    if [ $? -ne 0 ]; then
        echo "Errors compiling " $FILE
        exit
    fi
done
ar qc libodepack.a *.o
rm *.o
cd -

#compile python module linking it with lodepack
$F2PY -L$LODEFOLDER -lodepack -c --f90flags='-ffree-form -ffree-line-length-none' --fcompiler=gnu95 --opt='-Ofast' solve_py.pyf general_math.f95 statevars_mod.f95 pars_mod.f95 ghk_flux.f95 caL13.f95 TRPV1.f95 subcellular.f95 CaMKII_plast.f95 AMPA.f95 NMDA.f95 CB1R.f95 qsort_c_module.f95 stims.f95 comp_part.f95 solve_py.f95 > mp.txt 2>&1

#remove libodepack after it is linked
rm $LODEFOLDER/libodepack.a

echo "----------------------"
echo "Checking for errors..."
echo "----------------------"
ERRS=`grep -i "err" -C 1 mp.txt`
if [ -z "$ERRS" ]; then
    echo "no errors found"
else
    echo $ERRS
    echo '- - - - - - - - - - - - - - -'
    echo 'for details check file mp.txt'
fi

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