Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)

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Accession:187605
The endocannabinoid (eCB) system is considered involved in synaptic depression. Recent reports have also linked eCBs to synaptic potentiation. However it is not known how eCB signaling may support such bidirectionality. To question the mechanisms of this phenomena in spike-timing dependent plasticity (STDP) at corticostriatal synapses, we combined electrophysiology experiments with biophysical modeling. We demonstrate that STDP is controlled by eCB levels and dynamics: prolonged and moderate levels of eCB lead to eCB-mediated long-term depression (eCB-tLTD) while short and large eCB transients produce eCB-mediated long-term potentiation (eCB-tLTP). Therefore, just like neurotransmitters glutamate or GABA, eCB form a bidirectional system.
Reference:
1 . Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, Berry H (2016) Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. Elife 5:e13185 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum spiny neuron;
Channel(s): I L high threshold; I Calcium; I_SERCA; I Cl, leak; Ca pump;
Gap Junctions:
Receptor(s): AMPA; NMDA; mGluR; Glutamate; IP3;
Gene(s):
Transmitter(s):
Simulation Environment: FORTRAN; Python;
Model Concept(s): Ion Channel Kinetics; Coincidence Detection; Parameter Fitting; Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; STDP; Calcium dynamics; Parameter sensitivity; G-protein coupled; Neuromodulation;
Implementer(s):
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; AMPA; NMDA; mGluR; Glutamate; IP3; I L high threshold; I Calcium; I_SERCA; I Cl, leak; Ca pump;
#!/bin/sh

# (c) 2016 - Ilya Prokin - isprokin@gmail.com - https://sites.google.com/site/ilyaprokin
# INRIA Rhone-Alpes
# STDP model : script automatically installing dependencies

UNAME=$(uname -a)
printf "Checking your os...\n$UNAME"

if echo $UNAME | grep -qi 'ubuntu' || echo $UNAME | grep -qi 'debian'; then
    sudo apt-get update
    sudo apt-get install gcc gfortran
    sudo apt-get install python-numpy python-scipy python-matplotlib
fi
if echo $UNAME | grep -qi 'fedora' || echo $UNAME | grep -qE 'fc[0-9]+'; then
    sudo yum install gcc gcc-gfortran
    sudo yum install redhat-rpm-config
    sudo yum install numpy scipy python-matplotlib
fi
if echo $UNAME | grep -qi 'arch' || echo $UNAME | grep -qi 'manjaro'; then
    sudo pacman -S gcc gcc-fortran
    sudo pacman -S python2 python2-numpy python2-scipy python2-matplotlib
fi
if echo $UNAME | grep -qi 'darwin'; then
    if type brew; then
        brew tap homebrew/science
        brew tap homebrew/python
        brew update && brew upgrade
        brew install gcc
        brew install python
        brew install numpy scipy matplotlib
    else
        echo 'Your OS is OSX, but "brew" command is not found. You can try to install dependencies manually'
    fi
fi

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