Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)

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Accession:187605
The endocannabinoid (eCB) system is considered involved in synaptic depression. Recent reports have also linked eCBs to synaptic potentiation. However it is not known how eCB signaling may support such bidirectionality. To question the mechanisms of this phenomena in spike-timing dependent plasticity (STDP) at corticostriatal synapses, we combined electrophysiology experiments with biophysical modeling. We demonstrate that STDP is controlled by eCB levels and dynamics: prolonged and moderate levels of eCB lead to eCB-mediated long-term depression (eCB-tLTD) while short and large eCB transients produce eCB-mediated long-term potentiation (eCB-tLTP). Therefore, just like neurotransmitters glutamate or GABA, eCB form a bidirectional system.
Reference:
1 . Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, Berry H (2016) Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. Elife 5:e13185 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum spiny neuron;
Channel(s): I L high threshold; I Calcium; I_SERCA; I Cl, leak; Ca pump;
Gap Junctions:
Receptor(s): AMPA; NMDA; mGluR; Glutamate; IP3;
Gene(s):
Transmitter(s):
Simulation Environment: FORTRAN; Python;
Model Concept(s): Ion Channel Kinetics; Coincidence Detection; Parameter Fitting; Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; STDP; Calcium dynamics; Parameter sensitivity; G-protein coupled; Neuromodulation;
Implementer(s):
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; AMPA; NMDA; mGluR; Glutamate; IP3; I L high threshold; I Calcium; I_SERCA; I Cl, leak; Ca pump;
!    -*- f95 -*-
module qsort_c_module

    implicit none
    public :: QsortC
    private :: Partition

    contains

    recursive subroutine QsortC(A)
        real*8, intent(in out), dimension(:) :: A
        integer :: iq
        if(size(A) > 1) then
            call Partition(A, iq)
            call QsortC(A(:iq-1))
            call QsortC(A(iq:))
        endif
    end subroutine QsortC

    subroutine Partition(A, marker)
        real*8, intent(in out), dimension(:) :: A
        integer, intent(out) :: marker
        integer :: i, j
        real*8 :: temp
        real*8 :: x      ! pivot point
        x = A(1)
        i= 0
        j= size(A) + 1
        do
            j = j-1
            do
                if (A(j) <= x) exit
                j = j-1
            end do
            i = i+1
            do
                if (A(i) >= x) exit
                i = i+1
            end do
            if (i < j) then
                ! exchange A(i) and A(j)
                temp = A(i)
                A(i) = A(j)
                A(j) = temp
            elseif (i == j) then
                marker = i+1
                return
            else
                marker = i
                return
            endif
        end do
    end subroutine Partition

end module qsort_c_module

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