Endocannabinoid dynamics gate spike-timing dependent depression and potentiation (Cui et al 2016)

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Accession:187605
The endocannabinoid (eCB) system is considered involved in synaptic depression. Recent reports have also linked eCBs to synaptic potentiation. However it is not known how eCB signaling may support such bidirectionality. To question the mechanisms of this phenomena in spike-timing dependent plasticity (STDP) at corticostriatal synapses, we combined electrophysiology experiments with biophysical modeling. We demonstrate that STDP is controlled by eCB levels and dynamics: prolonged and moderate levels of eCB lead to eCB-mediated long-term depression (eCB-tLTD) while short and large eCB transients produce eCB-mediated long-term potentiation (eCB-tLTP). Therefore, just like neurotransmitters glutamate or GABA, eCB form a bidirectional system.
Reference:
1 . Cui Y, Prokin I, Xu H, Delord B, Genet S, Venance L, Berry H (2016) Endocannabinoid dynamics gate spike-timing dependent depression and potentiation. Elife 5:e13185 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Neostriatum spiny neuron;
Channel(s): I L high threshold; I Calcium; I_SERCA; I Cl, leak; Ca pump;
Gap Junctions:
Receptor(s): AMPA; NMDA; mGluR; Glutamate; IP3;
Gene(s):
Transmitter(s):
Simulation Environment: FORTRAN; Python;
Model Concept(s): Ion Channel Kinetics; Coincidence Detection; Parameter Fitting; Synaptic Plasticity; Long-term Synaptic Plasticity; Signaling pathways; STDP; Calcium dynamics; Parameter sensitivity; G-protein coupled; Neuromodulation;
Implementer(s):
Search NeuronDB for information about:  Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; AMPA; NMDA; mGluR; Glutamate; IP3; I L high threshold; I Calcium; I_SERCA; I Cl, leak; Ca pump;
!    -*- f95 -*-
! (c) 2016 - Ilya Prokin - isprokin@gmail.com - https://sites.google.com/site/ilyaprokin
! INRIA Rhone-Alpes
! STDP model : This module converts python definitions of model's variables to FORTRAN95 derived data type.
module statevars_mod
    implicit none
    type StateVariables_type
        real*8, pointer :: y_CamKII(:)
        real*8, pointer :: PP1
        real*8, pointer :: V
        real*8, pointer :: Ca_cyt
        real*8, pointer :: o_CB1R
        real*8, pointer :: o_NMDA
        real*8, pointer :: Ca_ER
        real*8, pointer :: m_caL13
        real*8, pointer :: I1P
        real*8, pointer :: h_caL13
        real*8, pointer :: AEA
        real*8, pointer :: IP3
        real*8, pointer :: h_CICR
        real*8, pointer :: DAG
        real*8, pointer :: d_CB1R
        real*8, pointer :: twoAG
        real*8, pointer :: d_AMPA
        real*8, pointer :: fpre
        real*8, pointer :: DAGLP
        real*8, pointer :: o_AMPA
    end type StateVariables_type
    contains
    subroutine SVs_get(SVs, y)
        type(StateVariables_type) :: SVs
        real*8, target :: y(32)
        SVs%y_CamKII => y(1:13)
        SVs%PP1 => y(14)
        SVs%V => y(15)
        SVs%Ca_cyt => y(16)
        SVs%o_CB1R => y(17)
        SVs%o_NMDA => y(18)
        SVs%Ca_ER => y(19)
        SVs%m_caL13 => y(20)
        SVs%I1P => y(21)
        SVs%h_caL13 => y(22)
        SVs%AEA => y(23)
        SVs%IP3 => y(24)
        SVs%h_CICR => y(25)
        SVs%DAG => y(26)
        SVs%d_CB1R => y(27)
        SVs%twoAG => y(28)
        SVs%d_AMPA => y(29)
        SVs%fpre => y(30)
        SVs%DAGLP => y(31)
        SVs%o_AMPA => y(32)
    end subroutine SVs_get
end module statevars_mod

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