CA1 pyramidal neuron synaptic integration (Bloss et al. 2016)

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Accession:187610
"... We examined synaptic connectivity between molecularly defined inhibitory interneurons and CA1 pyramidal cell dendrites using correlative light-electron microscopy and large-volume array tomography. We show that interneurons can be highly selective in their connectivity to specific dendritic branch types and, furthermore, exhibit precisely targeted connectivity to the origin or end of individual branches. Computational simulations indicate that the observed subcellular targeting enables control over the nonlinear integration of synaptic input or the initiation and backpropagation of action potentials in a branchselective manner. Our results demonstrate that connectivity between interneurons and pyramidal cell dendrites is more precise and spatially segregated than previously appreciated, which may be a critical determinant of how inhibition shapes dendritic computation."
Reference:
1 . Bloss EB, Cembrowski MS, Karsh B, Colonell J, Fetter RD, Spruston N (2016) Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells. Neuron [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration;
Implementer(s): Cembrowski, Mark S [cembrowskim at janelia.hhmi.org];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; Gaba; I Na,t; I K;
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//
// Code by Mark Cembrowski, Janelia Research Campus, 2015-16.
// Correspondence can be addressed to cembrowskim@janelia.hhmi.org
// 
// Computational modeling involved in Bloss, Cembrowski, Karsh, Colonell,
// Fetter, and Spruston, Neuron, 2016.
//
// The enclosed code distributes excitation and inhibition (the latter in a 
// genotype-specific manner) across the dendritic arbor and provides scripts
// for the easy simulation of inputs onto CA1 pyramidal cells.
//
// To load in the NEURON simulation environment:
// 1. Download and install NEURON (http://www.neuron.yale.edu/neuron/) if needed
// 2. Compile the arrayTomography directory via mknrndll. For help, see:
//    MSWindows: https://www.neuron.yale.edu/neuron/static/docs/nmodl/mswin.html
//    MacOS: http://www.neuron.yale.edu/neuron/static/docs/nmodl/macos.html
// 3. Launch start.hoc in the NEURON simulation environment.
//
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