Pleiotropic effects of SCZ-associated genes (Mäki-Marttunen et al. 2017)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:187615
Python and MATLAB scripts for studying the dual effects of SCZ-related genes on layer 5 pyramidal cell firing and sinoatrial node cell pacemaking properties. The study is based on two L5PC models (Hay et al. 2011, Almog & Korngreen 2014) and SANC models (Kharche et al. 2011, Severi et al. 2012).
Reference:
1 . Mäki-Marttunen T, Lines GT, Edwards AG, Tveito A, Dale AM, Einevoll GT, Andreassen OA (2017) Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling. Transl Psychiatry 7:5 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Cardiac atrial cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; Na/Ca exchanger; I_SERCA; Na/K pump; Kir;
Gap Junctions:
Receptor(s):
Gene(s): Nav1.1 SCN1A; Cav3.3 CACNA1I; Cav1.3 CACNA1D; Cav1.2 CACNA1C;
Transmitter(s):
Simulation Environment: NEURON; MATLAB; Python;
Model Concept(s): Schizophrenia;
Implementer(s): Maki-Marttunen, Tuomo [tuomo.maki-marttunen at tut.fi];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium; I A, slow; Na/Ca exchanger; I_SERCA; Na/K pump; Kir;
/
pleiotropy
hay
models
morphologies
Ca_HVA.mod *
Ca_LVAst.mod *
CaDynamics_E2.mod *
epsp.mod *
Ih.mod *
Im.mod *
K_Pst.mod *
K_Tst.mod *
Nap_Et2.mod *
NaTa_t.mod *
NaTs2_t.mod *
SK_E2.mod *
SKv3_1.mod *
calcifcurves.py
calcsteadystate.py
collectfig1.py
collectfig2.py
fig1_curves.mat
fig2_curves.mat
findDCshortthreshold.py
mutation_stuff.py *
mytools.py *
runme.sh *
scalings_cs.sav
                            
:Comment :
:Reference : :		Characterization of a Shaw-related potassium channel family in rat brain, The EMBO Journal, vol.11, no.7,2473-2486 (1992)

NEURON	{
	SUFFIX SKv3_1
	USEION k READ ek WRITE ik
	RANGE gSKv3_1bar, gSKv3_1, ik, offma, offmt, sloma, slomt, taummax
}

UNITS	{
	(S) = (siemens)
	(mV) = (millivolt)
	(mA) = (milliamp)
}

PARAMETER	{
	gSKv3_1bar = 0.00001 (S/cm2) 
	offma = 18.7 (mV)
	offmt = -46.56 (mV)
	sloma = 9.7 (mV)
	slomt = 44.14 (mV)
	taummax = 4.0 (ms)
}

ASSIGNED	{
	v	(mV)
	ek	(mV)
	ik	(mA/cm2)
	gSKv3_1	(S/cm2)
	mInf
	mTau
}

STATE	{ 
	m
}

BREAKPOINT	{
	SOLVE states METHOD cnexp
	gSKv3_1 = gSKv3_1bar*m
	ik = gSKv3_1*(v-ek)
}

DERIVATIVE states	{
	rates()
	m' = (mInf-m)/mTau
}

INITIAL{
	rates()
	m = mInf
}

PROCEDURE rates(){
	UNITSOFF
		mInf =  1/(1+exp((offma - v)/sloma))
		mTau =  taummax/(1+exp((offmt-v)/slomt))
	UNITSON
}

Loading data, please wait...