Striatal Spiny Projection Neuron (SPN) plasticity rule (Jedrzejewska-Szmek et al 2016)

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Accession:189153

Reference:
1 . Jedrzejewska-Szmek J, Damodaran S, Dorman DB, Blackwell KT (2017) Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons. Eur J Neurosci 45:1044-1056 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA; NMDA; GabaA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: GENESIS;
Model Concept(s): Calcium dynamics; Synaptic Plasticity;
Implementer(s): Jedrzejewska-Szmek, Joanna ; Damodaran, Sriraman ; Dorman, Daniel B ; Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  GabaA; AMPA; NMDA; Glutamate;
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SP12
chemsis_files
chemesisREADME
chemesis2.6.tgz
                            
place the chemesis2.6.tgz file into your genesis-2.4 directory.  I.e., when you downloaded and installed genesis-2.4, it created
genesis-2.4/genesis
after moving chemesis2.6.tgz into genesis-2.4, then
ls genesis-2.4/ shows
chemesis2.6.tgz genesis 
extract the files by typing:
tar -xzf chemesis2.6.tgz
then  "ls genesis-2.4/" shows
chan  chemesis2.6.tgz  chemesisREADME  genesis  Makefile
then type "make" (though you might have to edit the Makefile if you changed the default linux installation in your genesis-2.4 Makefile)
This will create and a few chemesis objects that did not get distributed with genesis2.4.  The most important one is caplas_synchan, which implements a calcium dependent plasticity channel.


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