Axonal HH-model for temperature stimulation (Fribance et al 2016)

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Accession:189155
"... To analyze the temperature effect, our study modified the classical HH axonal model by incorporating a membrane capacitance-temperature relationship. The modified model successfully simulated the generation and propagation of action potentials induced by a rapid increase in local temperature when the Curie temperature of membrane capacitance is below 40 °C, while the classical model failed to simulate the axonal excitation by temperature stimulation. The new model predicts that a rapid increase in local temperature produces a rapid increase in membrane capacitance, which causes an inward membrane current across the membrane capacitor strong enough to depolarize the membrane and generate an action potential. ..."
Reference:
1 . Fribance S, Wang J, Roppolo JR, de Groat WC, Tai C (2016) Axonal model for temperature stimulation. J Comput Neurosci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Squid axon;
Channel(s): I_K,Na;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Action Potential Initiation;
Implementer(s): Wang, Jicheng [jiw23 at pitt.edu]; Tai, Changfeng ;
Search NeuronDB for information about:  I_K,Na;
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