Fast AMPA receptor signaling (Geiger et al 1997)

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Accession:19022
Glutamatergic transmission at a principal neuron-interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis and modeling. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.
Reference:
1 . Geiger JR, Lübke J, Roth A, Frotscher M, Jonas P (1997) Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron 18:1009-23 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s): Roth, Arnd ;
Search NeuronDB for information about:  AMPA; Glutamate;
/* Current clamp simulation of dentate gyrus basket cell from Joerg Geiger and Peter Jonas     */
/* See Geiger et al., Neuron 18, 1009-1023, 1997                            */
/* Cell "GCBC0712"                                                          */ 
/* NEURON 3.0 file by Arnd Roth                                             */
/* currentclamp.hoc    Version 1.0 for nrniv       15.3.1996                */
/* ------------------------------------------------------------------------ */
/* usage: special currentclamp.hoc -                                        */
/* compile special first: nrnivmodl                                         */
/* line above modified to reflect compilation taking place in dir with files - tmm 10/02 */
load_file("nrngui.hoc")		/* updates file to nrn 5 10/25/2002 TMM */

xopen("stdRun.hoc")             /* load the standard NEURON hoc library */

/* initial parameters */
t = 0                           /* simulation starts at t = 0 ms */
dt = 0.25                      /* orig simulation time step = 0.005 ms */
steps_per_ms = 4		// controls number of graphed points tmm 11/19/02
tstop = 43                      /* orig simulation ends at t = 25 ms */
Vrest = -70                     /* resting potential, mV */
axialresist = 150               /* axial resistivity in ohm*cm */
membraneresist =10000           /* membrane resistivity in ohm*cm^2 */
membranecap = 0.8               /* membrane capacity in uF/cm^2 */

xopen("GCBC0712_6.nrn")         /* load the description of the morphology */
forall {insert pas g_pas=1/membraneresist e_pas=Vrest}
forall {v=Vrest Ra=axialresist cm=membranecap}
topology()                      /* draw an ascii dendrogram */

file_use = 0

proc stdinit() {                /* customize some functions from stdRun.hoc */
	realtime=0 startsw()
	init()
	initPlot()
	if (file_use) {
		wopen("outfile.1")
		fprint("%12s %12s %12s\n","time/ms", "soma/mV", "dend/mV")
	}
}

proc advance() {
	fadvance()
	if (file_use) {
		if (t < tstop-dt) {fprint("%12.4f %12.4f %12.4f\n", t, soma.v(0.5), dend4_11211.v(1))}
	}
	/* write output to file */
	/* t in ms, voltage at soma.v(0.5) in mV, voltage at dend4_11211.v(1), spacing = dt */
}

/* set up various GUI facilities */

// load_proc("nrnmainmenu")	// Duplicates nrngui.hoc's main menu TMM 11/19/02
// nrnmainmenu()

// use box'es to organize

objref outerbox1, outerbox2, innerbox1, innerbox2
outerbox1 = new VBox()
outerbox1.intercept(1)

  innerbox1 = new HBox()

  innerbox1.intercept(1)

    load_proc("nrncontrolmenu")
    nrncontrolmenu()

    xpanel("crude fig8d")
    xlabel("The below will execute")
    xlabel("an approximate")
    xlabel("version of figure 8d")
    xbutton("Estimate of fig 8d","load_file(\"fig8d.hoc\")")
    xlabel("For more accuracy")
    xlabel("modify fig8d.hoc")
    xlabel("to decrease the")
    xlabel("step size (dt), ")
    xlabel("and step size of ")
    xlabel("offset which is")
    xlabel("currently set to 4")
    xpanel()

    load_template("MenuExplore")
    objectvar menu_explore
    menu_explore = new MenuExplore()
    
    load_template("PointProcessLocator")
    objectvar pplocator[4]
    
    innerbox1.intercept(0)
  innerbox1.map()

  innerbox2 = new HBox()

  innerbox2.intercept(1)
    /* parameters of synapses */

    objectvar mySynapse[3]

	access dend2_1
	mySynapse[0] = new syn2(1)
	mySynapse[0].onset = 1.0      /* ms */
	mySynapse[0].tau0 = 0.08      /* ms */
	mySynapse[0].tau1 = 0.20       /* ms */
        mySynapse[0].e = -5           /* mV */
	mySynapse[0].gmax = 0.008     /* umho */
	pplocator[0] = new PointProcessLocator(mySynapse[0])

	access dend2_12
	mySynapse[1] = new syn2(0.6375)
	mySynapse[1].onset = 1.0      /* ms */
	mySynapse[1].tau0 = 0.08      /* ms */
	mySynapse[1].tau1 = 0.20       /* ms */
        mySynapse[1].e = -5           /* mV */
	mySynapse[1].gmax = 0.008     /* umho */
	pplocator[1] = new PointProcessLocator(mySynapse[1])

	access dend3_1
	mySynapse[2] = new syn2(0.95)
	mySynapse[2].onset = 1.0      /* ms */
	mySynapse[2].tau0 = 0.08      /* ms */
	mySynapse[2].tau1 = 0.20       /* ms */
        mySynapse[2].e = -5           /* mV */
	mySynapse[2].gmax = 0.008     /* umho */
	pplocator[2] = new PointProcessLocator(mySynapse[2])

	access soma                   /* current clamp at the center of soma */
	objectvar myStimulus
	myStimulus = new IClamp(0.5)
	myStimulus.del = 5    /* ms */
	myStimulus.dur = 0.5  /* ms */
	myStimulus.amp = 0.0  /* nA */
	pplocator[3] = new PointProcessLocator(myStimulus)

	innerbox2.intercept(0)
  innerbox2.map()
  outerbox1.intercept(0)
outerbox1.map()

outerbox2 = new VBox()
outerbox2.intercept(1)

    /* window for plotting EPSPs */

    objectvar save_window_
    objectvar scene_vector_[1]
    {
    save_window_ = new Graph(0)
    save_window_.size(0,40,-75,-45)
    save_window_.label(0.81, 0.01, "ms")
    save_window_.label(0.01, 0.81, "mV")
    scene_vector_[0] = save_window_
    {save_window_.view(0, -70, 40, 5, 540, 300, 300, 220)}
    graphList[0].append(save_window_)
    save_window_.save_name("graphList[0].")
    save_window_.addexpr("dend4_11211.v(1)", 3, 1, 4, -66)
    save_window_.addexpr("soma.v(0.5)", 1, 1, 4, -67)
    }

    /* draw the morphology of the cell */
    
    objectvar s
    s = new PlotShape()
    flush_list.append(s)
    s.save_name("flush_list.")
    
    outerbox2.intercept(0)

outerbox2.map()

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