Effects of electric fields on cognitive functions (Migliore et al 2016)

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Accession:190559
The paper discusses the effects induced by an electric field at power lines frequency on neuronal activity during cognitive processes.
Reference:
1 . Migliore R, De Simone G, Leinekugel X, Migliore M (2017) The possible consequences for cognitive functions of external electric fields at power line frequency on hippocampal CA1 pyramidal neurons. Eur J Neurosci 45:1024-1031 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Extracellular Fields; Gamma oscillations; Pattern Recognition; Spatio-temporal Activity Patterns;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]; Migliore, Rosanna [rosanna.migliore at cnr.it];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; AMPA; I Na,t; I A; I K; I h; Glutamate;
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MiglioreEJN2016
readme.html
distr.mod *
distr2.mod
fzap.mod *
Gfluct.mod
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
netstimm.mod *
xtrau.mod *
anatscale.hoc *
biophys.hoc
biophysPLAST.hoc
calcd.hoc
calcrxcu.hoc
ef_fig.png
efheader.hoc *
fig1B.hoc
fixnseg.hoc *
freq50.xfm
geo5038804.hoc *
init.hoc
interpxyzu.hoc *
LTDran.hoc
media-st er.xfm
mosinit.hoc
Napical.txt
no_ef_fig.png
Plast.hoc
setnseg.hoc *
setpointersu.hoc *
soma.hoc
synapses.hoc
voltage.ses
zapstimu.hoc
                            
load_file("nrngui.hoc")

load_file("geo5038804.hoc")
numbasal  = 52
numapical = 70
numuser5  = 49

load_file("biophys.hoc")
load_file("synapses.hoc")
load_file("efheader.hoc")



tstop=500

proc init() {

  t=0

  
  finitialize(Vrest)

	forall {
		v = Vrest
		if(ismembrane("nax") || ismembrane("na3")) {
			ena=55
		}
		if(ismembrane("kdr") || ismembrane("kap") || ismembrane("kad")) {
			ek=-90
		}
		if(ismembrane("hd")) {
			ehd_hd=-30
		}
	}

	finitialize(Vrest)
	fcurrent()

	forall {
		for(x) {
			if(ismembrane("na3") || ismembrane("nax")) {
				e_pas(x)=v(x)+(ina(x)+ik(x))/g_pas(x)
			}
			if(ismembrane("hd")) {
				e_pas(x)=e_pas(x)+i_hd(x)/g_pas(x)
			}
		}
	}

	for i = 0, nsyn-1 {
  		st[i].seed(114)
	}

}



load_file("voltage.ses")
objref vp
vp = save_window_
vp.exec_menu("Keep Lines")
proc sim() {
  vp.erase_all()

	vp.label(0.949956, 0.931495, "no EF", 2, 1, 0, 0, 1)
	vp.label(0.950834, 0.878114, "EF", 2, 1, 0, 0, 2)
  vp.brush(2)
  vp.color(1)
  vp.addvar("", "v(0.5)")
  setstim(0, 1200, 50, 50, 0)
  changefield(100, 90, 90)
  run()

  vp.color(2)
  vp.addexpr("", "v(0.5)")
  setstim(0, 1200, 50, 50, 40)
  changefield(100, 90, 90)
  run()

}


xpanel("electric field sim")
xbutton("Run sims", "sim()")
xpanel(255,672)



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