Activity dependent regulation of pacemaker channels by cAMP (Wang et al 2002)

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Accession:19176
Demonstration of the physiological consequences of the cyclic allosteric gating scheme for Ih mediated by HCN2 in thalamocortical relay cells.
Reference:
1 . Wang J, Chen S, Nolan MF, Siegelbaum SA (2002) Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. Neuron 36:451-61 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I K,leak; I h;
Gap Junctions:
Receptor(s):
Gene(s): HCN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics;
Implementer(s): Nolan, Matt [mfnolan at fido.cpmc.columbia.edu]; Chen, Shan [sc448 at columbia.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; I K,leak; I h;
/*
	Template file for a single compartment model of a thalamocortical neuron modified from the model described by Destexhe et al, 1995.
	
	Destexhe, A., Bal, T., McCormick, D.A. and Sejnowski, T.J.
	Ionic mechanisms underlying synchronized oscillations and propagating
	waves in a model of ferret thalamic slices. Journal of Neurophysiology
	76: 2049-2070, 1996.
	See also http://www.cnl.salk.edu/~alain , http://cns.fmed.ulaval.ca
*/

begintemplate sTC		// create a new template object
public soma , kl

create soma[1]			// one compartment of about 29000 um2
soma {
  nseg = 1
  diam = 96
  L = 96
  cm = 1
}

objectvar kl

proc init() { local v_potassium, v_sodium

objectvar kl
kl = new kleak()


  v_potassium = -100		// potassium reversal potential 
  v_sodium = 50			// sodium reversal potential 

soma {
	diam = 96		// geometry 
	L = 96			// so that area is about 29000 um2
	nseg = 1
	Ra = 100

	insert pas		// leak current 
	e_pas = -70		// from Rinzel
	g_pas = 1e-5

	kl.loc(0.5)		// K-leak
	Erev_kleak = v_potassium
	kl.gmax = 0.004		// (uS)
				// conversion: x(uS) = x(mS/cm2)*29000e-8*1e3
				//		     = x(mS/cm2) * 0.29


	insert hh2		// Hodgin-Huxley INa and IK 
	ek = v_potassium
	ena = v_sodium
	vtraub_hh2 = -25	// High threshold to simulated IA
	gnabar_hh2 = 0.09
	gkbar_hh2 = 0.01
	
	insert hcn2		// model for HCN2 current
	gbar_hcn2 = 0.01	// maximal conductance
	a_hcn2 = 40e-9	// cAMP concentration
	gca_hcn2 = 1		// relative conductance of the bound state
	shift_hcn2 = 48	// shift in voltage dependence

  }
}
endtemplate sTC




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