Activity dependent regulation of pacemaker channels by cAMP (Wang et al 2002)

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Accession:19176
Demonstration of the physiological consequences of the cyclic allosteric gating scheme for Ih mediated by HCN2 in thalamocortical relay cells.
Reference:
1 . Wang J, Chen S, Nolan MF, Siegelbaum SA (2002) Activity-dependent regulation of HCN pacemaker channels by cyclic AMP: signaling through dynamic allosteric coupling. Neuron 36:451-61 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I K,leak; I h;
Gap Junctions:
Receptor(s):
Gene(s): HCN2;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Ion Channel Kinetics;
Implementer(s): Nolan, Matt [mfnolan at fido.cpmc.columbia.edu]; Chen, Shan [sc448 at columbia.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; I K,leak; I h;
COMMENT
Mechanism to clamp intracellular cAMP concentration.
ENDCOMMENT

NEURON {
	SUFFIX cAMPclamp
	RANGE del, dur, conc1, conc2
	USEION a  WRITE ai  VALENCE 0
}
UNITS {
        (nA) = (nanoamp)
        (molar) = (1/litre)
}

PARAMETER {
	del (ms)
	dur (ms)      <0,1e9>
        conc1 (molar)   
        conc2 (molar)  
}
ASSIGNED { ai (molar) }

INITIAL {
	ai = conc1
}

BREAKPOINT {
	at_time(del)
	at_time(del+dur)

	if (t < del + dur && t > del) {
		ai = conc2
	}else{
		ai = conc1
	}
}

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