Dendritic L-type Ca currents in motoneurons (Carlin et al 2000)

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Accession:19491
A component of recorded currents demonstrated kinetics consistent with a current originating at a site spatially segregated from the soma. In response to step commands this component was seen as a late-onset, low amplitude persistent current whilst in response to depolarizing-repolarizing ramp commands a low voltage clockwise current hysteresis was recorded. Simulations using a neuromorphic motoneuron model could reproduce these currents only if a noninactivating calcium conductance was placed in the dendritic compartments.
Reference:
1 . Carlin KP, Jones KE, Jiang Z, Jordan LM, Brownstone RM (2000) Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. Eur J Neurosci 12:1635-46 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I L high threshold; I N; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Dendritic Bistability;
Implementer(s): Jones, Kelvin E [KEJones at ualberta.ca];
Search NeuronDB for information about:  I L high threshold; I N; I Calcium;
// fig3A.hoc generates an approx to fig3A
// based on init.hoc whose header lines follow:
// this file is loaded after fig_3aleft.hoc

proc insert_all_ca() {
	forall	{
		insert N_Ca
		insert L_Ca
		insert L_HVA_Ca
	}
}

proc all_ca_off() {
	forall	{
		gcabar_N_Ca = 0
		gcabar_L_Ca = 0
		gcabar_L_HVA_Ca = 0
	}
}


objref dendBox

dendBox = new VBox()


insert_all_ca()

all_ca_off()
xopen("memb_N_dend.hoc")	//active and passive membrane properties of the model,
Graph[0].exec_menu("Erase")

g[0].exec_menu("Keep Lines")
g[3].color(2)
execute("varyamp(1)",Electrode[0])	// equiv to pressing "vary test level"

	addGraph(3,dendBox)

all_ca_off()
xopen("memb_LLVA_dend.hoc")	//active and passive membrane properties of the model,

g[4].color(2)
Graph[0].exec_menu("Erase")
execute("varyamp(1)",Electrode[0])	// equiv to pressing "vary test level"

	addGraph(4,dendBox)

all_ca_off()
xopen("memb_LHVA_dend.hoc")	//their locations and densities

g[5].color(3)
Graph[0].exec_menu("Erase")
execute("varyamp(1)",Electrode[0])	// equiv to pressing "vary test level"
	addGraph(5,dendBox)

dendBox.intercept(1)
        {Graph[1].view(0, -80, 700, 120, 631, win_top, win_width, win_height)}
dendBox.intercept(0)

dendBox.intercept(0)
dendBox.map("fig3aright",40,120,-1,-1)

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