Dendritic L-type Ca currents in motoneurons (Carlin et al 2000)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:19491
A component of recorded currents demonstrated kinetics consistent with a current originating at a site spatially segregated from the soma. In response to step commands this component was seen as a late-onset, low amplitude persistent current whilst in response to depolarizing-repolarizing ramp commands a low voltage clockwise current hysteresis was recorded. Simulations using a neuromorphic motoneuron model could reproduce these currents only if a noninactivating calcium conductance was placed in the dendritic compartments.
Reference:
1 . Carlin KP, Jones KE, Jiang Z, Jordan LM, Brownstone RM (2000) Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. Eur J Neurosci 12:1635-46 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I L high threshold; I N; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Dendritic Bistability;
Implementer(s): Jones, Kelvin E [KEJones at ualberta.ca];
Search NeuronDB for information about:  I L high threshold; I N; I Calcium;
objref hidden_graph_list, hidden_xvec, hidden_yvec, hidden_g1, hidden_g2
hidden_xvec = new Vector()
hidden_yvec = new Vector()

// calling format is graphlinecopy(graphObject1, graphObject2)
// all the lines are copied from the 1 graph to the 2 graph

proc graphlinecopy() {	local j, i
	j=0
 	hidden_g1=$o1
 	hidden_g2=$o2
//	hidden_g2.exec_menu("Erase")
	hidden_g2.exec_menu("Keep Lines")
	for (i=-1; (i = hidden_g1.getline(j, hidden_xvec, hidden_yvec) != -1)&&(j<200) ; j+=1 ) {
		// xvec and yvec contain the line with Graph internal index i.
		// and can be associated with the sequential index j.
		// print i,j
		if (j>=1) {
			hidden_yvec.label("")	// blank out labels
		}
		hidden_yvec.line(hidden_g2,hidden_xvec)	// use default color on $o2
      }
}

Loading data, please wait...