Dendritic L-type Ca currents in motoneurons (Carlin et al 2000)

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Accession:19491
A component of recorded currents demonstrated kinetics consistent with a current originating at a site spatially segregated from the soma. In response to step commands this component was seen as a late-onset, low amplitude persistent current whilst in response to depolarizing-repolarizing ramp commands a low voltage clockwise current hysteresis was recorded. Simulations using a neuromorphic motoneuron model could reproduce these currents only if a noninactivating calcium conductance was placed in the dendritic compartments.
Reference:
1 . Carlin KP, Jones KE, Jiang Z, Jordan LM, Brownstone RM (2000) Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. Eur J Neurosci 12:1635-46 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I L high threshold; I N; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Dendritic Bistability;
Implementer(s): Jones, Kelvin E [KEJones at ualberta.ca];
Search NeuronDB for information about:  I L high threshold; I N; I Calcium;
//This is the main file to call from the command line. By calling this file the
//associated files making up the component structure of the model will be loaded.
// AUTHOR: Kelvin Jones
// DATE: 980728

load_file("nrngui.hoc")		// for compatibility with Windows version

xopen("morphology.hoc")		//retrieves the file with the morphological description
					//and names of the components of the model

xopen("memb_Lboth.hoc")	//retrieves the file with the descriptions of the
					//active and passive membrane properties of the model,
					//their locations and densities

access soma

xopen("ramp.ses")			// brings up the default windows

celsius = 36				// I put this here to make sure it doesn't
					// get changed by a ses file
forall eca=60


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