Dendritic L-type Ca currents in motoneurons (Carlin et al 2000)

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Accession:19491
A component of recorded currents demonstrated kinetics consistent with a current originating at a site spatially segregated from the soma. In response to step commands this component was seen as a late-onset, low amplitude persistent current whilst in response to depolarizing-repolarizing ramp commands a low voltage clockwise current hysteresis was recorded. Simulations using a neuromorphic motoneuron model could reproduce these currents only if a noninactivating calcium conductance was placed in the dendritic compartments.
Reference:
1 . Carlin KP, Jones KE, Jiang Z, Jordan LM, Brownstone RM (2000) Dendritic L-type calcium currents in mouse spinal motoneurons: implications for bistability. Eur J Neurosci 12:1635-46 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I L high threshold; I N; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Dendritic Bistability;
Implementer(s): Jones, Kelvin E [KEJones at ualberta.ca];
Search NeuronDB for information about:  I L high threshold; I N; I Calcium;
objectvar save_window_, rvp_
objectvar scene_vector_[5]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(5,41,1)}

//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
soma ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("NetStim") i = mt.selected()
ms[i] = new MechanismStandard("NetStim")
ms[i].set("interval", 10, 0)
ms[i].set("number", 10, 0)
ms[i].set("start", 50, 0)
ms[i].set("noise", 0, 0)
mt.select("R_VClamp") i = mt.selected()
ms[i] = new MechanismStandard("R_VClamp")
ms[i].set("dur", 100, 0)
ms[i].set("dur", 20000, 1)
ms[i].set("dur", 100, 2)
ms[i].set("amp", -120, 0)
ms[i].set("amp", -180, 1)
ms[i].set("amp", -120, 2)
ms[i].set("gain", 100000, 0)
ms[i].set("rstim", 1, 0)
ms[i].set("tau1", 0.001, 0)
ms[i].set("tau2", 0, 0)
ms[i].set("e0", 0.0015848, 0)
ms[i].set("vo0", -158.48, 0)
ms[i].set("vi0", -120, 0)
ms[i].set("fac", 0, 0)
mt.select("R_VClamp") i = mt.selected() maction(i)
hoc_ac_ = 0.5
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 293, 276, 350.4, 480)
}
objref ocbox_
//End PointProcessManager

{
xpanel("NEURON Main Panel", 0)
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 13032
xvalue("Real Time","realtime", 0,"", 0, 1 )
celsius = 36
xvalue("celsius","celsius", 1,"", 0, 1 )
global_ra = 70
xvalue("global_Ra","global_ra", 1,"set_ra()", 1, 1 )
xbutton("RunControl","nrncontrolmenu()")
xmenu("New Graph", 0)
xbutton("Voltage axis","newPlotV()")
xbutton("Current axis","newPlotI()")
xbutton("State axis","newPlotS()")
xbutton("Shape plot","newshapeplot()")
xbutton("Vector movie","newvectorplot()")
xbutton("Phase Plane","newphaseplane()")
xbutton("Grapher","load_proc(\"makegrapher\") makegrapher(1)")
xmenu()
xmenu("Point Processes", 0)
xmenu("Managers", 0)
xbutton("Point Manager","load_template(\"PointProcessManager\") makeppm()")
xbutton("Point Group","load_template(\"PointProcessGroupManager\") makeppgm()")
xbutton("Electrode","load_proc(\"makeelectrode\") makeelectrode()")
xmenu()
xmenu("Viewers", 0)
xmenu("PointProcesses", 0)
xbutton("IClamp","makePointBrowser(\"IClamp\")")
xbutton("AlphaSynapse","makePointBrowser(\"AlphaSynapse\")")
xbutton("KSyn","makePointBrowser(\"KSyn\")")
xbutton("SEClamp","makePointBrowser(\"SEClamp\")")
xbutton("VClamp","makePointBrowser(\"VClamp\")")
xbutton("APCount","makePointBrowser(\"APCount\")")
xbutton("RClamp","makePointBrowser(\"RClamp\")")
xbutton("R_SEClamp","makePointBrowser(\"R_SEClamp\")")
xbutton("R_VClamp","makePointBrowser(\"R_VClamp\")")
xmenu()
xmenu()
xmenu()
xmenu("Distributed Mechanisms", 0)
xmenu("Managers", 0)
xbutton("Inserter","load_template(\"Inserter\") makeinserter()")
xbutton("Homogeneous Spec","load_proc(\"makeshowmechanism\") makeshowmechanism()")
xmenu()
xmenu("Viewers", 0)
xbutton("Shape Name","load_template(\"MenuExplore\") makeMenuExplore()")
xbutton("Name Values","nrnallsectionmenu()")
xmenu("Mechanisms (Globals)", 0)
xbutton("na_ion","nrnglobalmechmenu(\"na_ion\")")
xbutton("k_ion","nrnglobalmechmenu(\"k_ion\")")
xbutton("hh","nrnglobalmechmenu(\"hh\")")
xbutton("ca_ion","nrnglobalmechmenu(\"ca_ion\")")
xbutton("HVA_Ca","nrnglobalmechmenu(\"HVA_Ca\")")
xbutton("L_Ca","nrnglobalmechmenu(\"L_Ca\")")
xbutton("L_HVA_Ca","nrnglobalmechmenu(\"L_HVA_Ca\")")
xbutton("N_Ca","nrnglobalmechmenu(\"N_Ca\")")
xmenu()
xmenu()
xmenu()
xmenu("Miscellaneous", 0)
xmenu("Clipboard", 0)
xbutton("Save to File","load_proc(\"clipboard_save\") clipboard_save()")
xbutton("Retrieve from File","load_proc(\"clipboard_retrieve\") clipboard_retrieve()")
xbutton("Gather Values","load_template(\"GatherVec\") makeGatherVec()")
xbutton("Vector Play","load_template(\"VectorPlay\") makeVectorPlay()")
xbutton("Vector Wrapper","load_template(\"VecWrap\") makeVecWrap()")
xmenu()
xmenu("Family", 0)
xbutton("Family","load_template(\"Family\") makeFamily()")
xbutton("Command","load_template(\"ExecCommand\") newcommand()")
xmenu()
xbutton("Parameterized Function","load_template(\"FunctionFitter\") makefitter()")
xbutton("Run Fitter","load_template(\"RunFitter\") makerunfitter()")
xmenu("Impedance", 0)
xbutton("Frequency","load_template(\"ImpedanceRatio\") makeImpRatio()")
xbutton("Path","load_template(\"Impx\") makeImpx()")
xbutton("log(A) vs x","load_template(\"LogAvsX\") makelogax()")
xbutton("Shape","load_template(\"ImpShape\") makeImpShape()")
xmenu()
xmenu()
xpanel(374,5)
}
{
save_window_ = new Graph(0)
save_window_.size(0,20200,-120,60)
scene_vector_[2] = save_window_
{save_window_.view(0, -120, 20200, 180, 642, 63, 489.6, 251.2)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 1, 1, 0.8, 0.9, 2)
}
{
save_window_ = new Graph(0)
save_window_.size(0,20200,-40,80)
scene_vector_[4] = save_window_
{save_window_.view(0, -40, 20200, 120, 642, 354, 488.64, 290.56)}
graphList[1].append(save_window_)
save_window_.save_name("graphList[1].")
save_window_.addexpr("R_VClamp[0].i", 1, 1, 0.659425, 0.98147, 2)
}
{
xpanel("RunControl", 0)
v_init = -65
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 5
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 20200
xvalue("t","t", 2 )
tstop = 20200
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.025
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 2
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xpanel(5,237)
}
objectvar scene_vector_[1]
{doNotify()}

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